"We continue to work on a process to complete action on this bill," said Reid, speaking from the Senate floor. "We are going to have to do that … We can't do that unless we get some basic cooperation, and it's a shame if we can't move forward on this bipartisan bill."

Reid then threatened to close debate by filing cloture if a reasonable agreement is not quickly reached. 

"If we can't find an agreement to move forward on this bill, I have no alternative but to try to stop the filibuster on that," he said.

It appeared on Wednesday there had been a breakthrough when Reid announced that Democrats would allow a vote on an amendment offered by Sen. Roy BluntRoy Dean BluntDems push for more money for opioid fight Trump asked Senate Republicans to end Russia election interference investigation: report An overlooked solution to the opioid epidemic MORE (R-Mo.) that would reverse the Obama's administration's controversial contraception decisions. At the time, Reid also suggested that there could be a number of votes on non-germane amendments on Thursday and that the Senate could complete work on the bill by the end of next week. 

The $109 billion spending bill has officially been pending since Feb. 9, when the Senate voted 85-11 to bring it to the floor.