The vote on the farm bill amendment on Tuesday was 45 to 54.
The chamber also voted against another amendment by DeMint that would prohibit the Secretary of Agriculture from making certain loan guarantees.
The chamber did, however, approve four amendments by voice Tuesday evening. Sen. Kay Hagan's (D-N.C.) amendment aimed at making crop insurance more accessible, DeMint's amendment expressing the sense of the Senate's disapproval if the farm bill interferes "with the free market," Sen. John Kerry's (D-Mass.) amendment extending emergency loan eligibility for commercial fishermen and Sen. Mary Landrieu's (D-La.) amendment modifying a section of the farm bill on rural development all passed.
Additionally, an amendment by DeMint that prohibits "mandatory or compulsory check off programs" was defeated in a vote of 20-79.