Sen. Marco RubioMarco Antonio RubioOvernight Regulation: Trump’s former chemical safety nominee leaving EPA | Senate confirms Powell as Fed chair | NTSB 'gathering information' on Tesla crash Overnight Cybersecurity: Mueller interviewed Sessions in Russia probe | Comey met investigators last year | Dems demand social media firms probe Russian bots | Missing FBI text messages anger Republicans Overnight Finance: Senate confirms Powell as Fed chair | Mulvaney declares 'new mission' for consumer bureau | Trump says solar tariffs will boost jobs MORE (R-Fla.) joined Sen. Rand PaulRandal (Rand) Howard PaulOvernight Regulation: Trump’s former chemical safety nominee leaving EPA | Senate confirms Powell as Fed chair | NTSB 'gathering information' on Tesla crash Overnight Finance: Senate confirms Powell as Fed chair | Mulvaney declares 'new mission' for consumer bureau | Trump says solar tariffs will boost jobs Senate confirms Jerome Powell as Fed chairman MORE's (R-Ky.) ongoing filibuster Wednesday afternoon on the Senate floor, and opened his time with a sly acknowledgment of his now infamous water bottle incident during his rebuttal to the State of the Union.

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Addressing Paul, who had been conducting the filibuster for nearly five hours, Rubio quipped that it was important to stay hydrated.

"Let me give you some free advice: Keep some water nearby," Rubio said.

While giving the Republican response to President Obama's annual address last month, Rubio became parched and grabbed for an off-screen water bottle. The awkward moment became the subject of jokes and ridicule on social media networks and liberal talk show programs.

Speaking Wednesday, Rubio went on to make reference to the winter weather hitting some of the Washington area, quipping that the ongoing filibuster effort was "great for people snowed in at home with nothing better to watch but C-SPAN." The capital city braced for what was expected to be a serious snowstorm on Wednesday, although forecast accumulation never materialized within the city limits.

Paul launched the filibuster Wednesday morning to protest the Obama Administration's refusal to absolutely rule out ever conducting a drone strike against American citizens on U.S. soil. In a letter to the Kentucky lawmaker, Attorney General Eric HolderEric Himpton HolderUber hires first-ever chief diversity and inclusion officer A law enforcement report card for Trump’s first year Obama planning to campaign and fundraise for Dems in 2018: report MORE said the administration had "no intention of doing so," but believed it had constitutional authority to do so in an “extraordinary circumstance" like Pearl Harbor or the September 11 attacks.

Throughout the proceedings, a bipartisan group of senators, including Rubio, Sen. Ted CruzRafael (Ted) Edward CruzTrump Commerce pick told lawmakers he would look at reversing Obama move on internet oversight: report Overnight Regulation: Trump’s former chemical safety nominee leaving EPA | Senate confirms Powell as Fed chair | NTSB 'gathering information' on Tesla crash Overnight Finance: Senate confirms Powell as Fed chair | Mulvaney declares 'new mission' for consumer bureau | Trump says solar tariffs will boost jobs MORE (R-Texas), Sen. Jerry MoranGerald (Jerry) MoranRepublicans divided over shorter stopgap funding bill Live coverage: Federal government on brink of shutdown Blame game ramps up as shutdown nears MORE (R-Kan.), Sen. Mike LeeMichael (Mike) Shumway LeeTrump Commerce pick told lawmakers he would look at reversing Obama move on internet oversight: report Overnight Regulation: Trump’s former chemical safety nominee leaving EPA | Senate confirms Powell as Fed chair | NTSB 'gathering information' on Tesla crash Overnight Finance: Senate confirms Powell as Fed chair | Mulvaney declares 'new mission' for consumer bureau | Trump says solar tariffs will boost jobs MORE (R-Utah), and Sen. Ron WydenRonald (Ron) Lee WydenCommunity health centers await funding that expired months ago Democrats mull keeping Senate in session overnight Top Dem presses Trump health official on potential ethics violation MORE (D-Ore.) have taken time to ask questions of Paul, prolonging the proceedings and giving the Kentucky lawmaker a chance to rest without yielding control of the Senate floor.

Rubio praised Paul on Wednesday, saying the Kentucky senator was performing an important constitutional duty.

"It is a constitutional obligation to ask relevant questions to public policy … if we’re not going to ask these questions, who will?" Rubio said.