Sen. Marco RubioMarco RubioRubio wades into Trump-Lewis feud 19 companies that Trump has tweeted about Ex-Dem gov: I would have picked Giuliani over Tillerson MORE (R-Fla.) joined Sen. Rand PaulRand PaulSanders, Dems defend ObamaCare at Michigan rally Paul: Medicaid expansion 'the big question' Rand Paul: ObamaCare replacement goal is to insure most people at lowest cost MORE's (R-Ky.) ongoing filibuster Wednesday afternoon on the Senate floor, and opened his time with a sly acknowledgment of his now infamous water bottle incident during his rebuttal to the State of the Union.

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Addressing Paul, who had been conducting the filibuster for nearly five hours, Rubio quipped that it was important to stay hydrated.

"Let me give you some free advice: Keep some water nearby," Rubio said.

While giving the Republican response to President Obama's annual address last month, Rubio became parched and grabbed for an off-screen water bottle. The awkward moment became the subject of jokes and ridicule on social media networks and liberal talk show programs.

Speaking Wednesday, Rubio went on to make reference to the winter weather hitting some of the Washington area, quipping that the ongoing filibuster effort was "great for people snowed in at home with nothing better to watch but C-SPAN." The capital city braced for what was expected to be a serious snowstorm on Wednesday, although forecast accumulation never materialized within the city limits.

Paul launched the filibuster Wednesday morning to protest the Obama Administration's refusal to absolutely rule out ever conducting a drone strike against American citizens on U.S. soil. In a letter to the Kentucky lawmaker, Attorney General Eric HolderEric H. HolderFormer AG launches redistricting effort to help Dems reclaim power The racism inquisition over Jeff Sessions Dem rep to Obama: Don’t ‘lay back’ after presidency MORE said the administration had "no intention of doing so," but believed it had constitutional authority to do so in an “extraordinary circumstance" like Pearl Harbor or the September 11 attacks.

Throughout the proceedings, a bipartisan group of senators, including Rubio, Sen. Ted CruzTed CruzGraham, Cruz proposal to defund the U.N. is misguided Right renews push for term limits as Trump takes power Dissenting nominees give hope to GOP skeptics of Trump MORE (R-Texas), Sen. Jerry MoranJerry MoranOvernight Tech: Tech listens for clues at Sessions hearing | EU weighs expanding privacy rule | Senators blast Backpage execs Senate rejects Paul's balanced budget Republicans add three to Banking Committee MORE (R-Kan.), Sen. Mike LeeMike LeeRight renews push for term limits as Trump takes power Conservatives press Trump on Supreme Court pick Overnight Finance: Ethics chief blasts Trump business plan | Senate begins late-night marathon vote | Lawmakers look to rein in Trump on trade MORE (R-Utah), and Sen. Ron WydenRon WydenWhy Trump should abolish the White House faith office Schumer puts GOP on notice over ObamaCare repeal Lawmakers condemn Trump for attack on John Lewis MORE (D-Ore.) have taken time to ask questions of Paul, prolonging the proceedings and giving the Kentucky lawmaker a chance to rest without yielding control of the Senate floor.

Rubio praised Paul on Wednesday, saying the Kentucky senator was performing an important constitutional duty.

"It is a constitutional obligation to ask relevant questions to public policy … if we’re not going to ask these questions, who will?" Rubio said.