The Senate rejected House Budget Committee Chairman Paul RyanPaul Davis RyanFive GOP lawmakers mulling bid to lead conservative caucus On The Money — Sponsored by Prudential — Trump walks back criticism of UK Brexit strategy | McConnell worries US in 'early stages' of trade war | US trade deficit with China hits new record Tampons sent to Dem who called for free feminine hygiene products in House MORE’s (R-Wis.) budget Thursday night.

Senate Budget Committee Chairwoman Patty MurrayPatricia (Patty) Lynn MurrayJane Fonda: Kavanaugh confirmation would be a 'catastrophe' Dems rip Trump DOJ nominee who represented Russian bank Dems grasp for way to stop Trump's Supreme Court pick MORE (D-Wash.) forced Senate Republicans to vote on Paul’s plan through an amendment she offered, which failed on a 40-59 vote.

GOP Sens. Susan CollinsSusan Margaret CollinsDem infighting erupts over Supreme Court pick McConnell: Senate to confirm Kavanaugh by Oct. 1 Overnight Health Care: Watchdog finds Tom Price improperly used funds on flights | Ex-Novartis CEO sent drug pricing proposal to Cohen | HHS staffers depart after controversial social media posts MORE (Maine), Dean HellerDean Arthur HellerJacky Rosen hits Dean Heller over health care in first negative ad GOP moderates hint at smooth confirmation ahead for Kavanaugh GOP senators introduce resolution endorsing ICE MORE (Nev.), Mike LeeMichael (Mike) Shumway LeeGOP moderates hint at smooth confirmation ahead for Kavanaugh GOP senators introduce resolution endorsing ICE GOP senator moves to restart Pentagon report on NATO allies' spending MORE (Utah), Rand PaulRandal (Rand) Howard PaulSunday shows preview: Trump readies for meeting with Putin McConnell: Senate to confirm Kavanaugh by Oct. 1 GOP moderates hint at smooth confirmation ahead for Kavanaugh MORE (Ky.) and Ted CruzRafael (Ted) Edward CruzThe Memo: Trump leaves chaos in his wake in UK Beto O'Rourke is dominating Ted Cruz in enthusiasm and fundraising — but he's still headed for defeat GOP senators introduce resolution endorsing ICE MORE (Texas) voted with Democrats against Ryan's plan. Sen. Marco RubioMarco Antonio RubioScottish beer company offering ‘tiny cans’ for Trump’s ‘tiny hands’ The Hill's Morning Report — Trump readies for Putin summit: 'He’s not my enemy’ Overnight Defense: Fallout from tense NATO summit | Senators push to block ZTE deal in defense bill | Blackwater founder makes new pitch for mercenaries to run Afghan war MORE (R-Fla.), a prospective 2016 GOP presidential nominee, voted for Ryan's budget.

"Enough is enough. Republicans received a vote on their extreme proposal; now that it has failed once more, it's time for Republicans to work with Democrats to enact a budget that reflects our values of fairness and opportunity for all," House Minority Leader Nancy Pelosi (D-Calif.) said after the vote.

Ahead of the vote, Sen. John ThuneJohn Randolph ThuneGOP senators introduce resolution endorsing ICE The real reason Scott Pruitt is gone: Putting a key voting bloc at risk Hillicon Valley: Lawmakers eye ban on Chinese surveillance cameras | DOJ walks back link between fraud case, OPM breach | GOP senators question Google on Gmail data | FCC under pressure to delay Sinclair merger review MORE (R-S.D.) urged his colleagues to support Ryan's budget.

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"The House Republican budget does something the Democrats' doesn’t do, it actually balances," Thune said. "If you look at the House Republican budget, it’s focused on growing the economy, not the government." 

Ryan’s budget passed in the House Thursday morning on a 221-207 vote. His plan would reform the tax code in order to pay for a tax rate deduction, among other things. Ryan would reduce the top tax rate to 25 percent — a reduction of more than 10 percentage points. 

Democrats have said that Ryan would have to raise taxes on the middle class by ending tax deductions that benefit families in order to pay for tax cuts to the wealthiest.

"Our budget uses new revenue from the wealthiest Americans and biggest corporations for deficit reduction, and for investments that support our economy and strengthen our middle class," Murray said. “But the House Republican budget would do the opposite."

Murray’s budget includes $100 billion in stimulus funding that she says would help boost economic growth and workforce training. Her plan has come under heavy fire from Republicans who say it over-estimates the extent to which it would reduce the deficit, and it raises nearly $1 trillion in new taxes. Democrats say their budget cuts the deficit by $1.85 trillion over 10 years through an equal amount of spending cuts and new revenue, but the GOP has said that because it assumes the sequester will not happen, the amount of deficit reduction is closer to $700 billion.

Murray said Americans prefer her "balanced" approach over Ryan's "unbalanced" plan because her plan includes revenue and spending cuts. She added that the public rejected Ryan's budget ideas in the November election.

"Americans want to see a budget that puts the middle class first, and asks the wealthiest Americans and biggest corporations to do their fair share towards deficit reduction," Murray said. “Unfortunately, rather than meeting the clear demands of the vast majority of the American people, House Republicans put forward a budget last week that doubles down on that rejected ideology."

Ryan balances the budget over 10 years with $5.7 trillion in projected spending cuts. Democrats have criticized his plan for "gutting" programs that benefit the middle class and turn Medicare into a voucher system.

Sen. Debbie StabenowDeborah (Debbie) Ann StabenowDem senator: Kavanaugh sides with 'wealthiest special interests' Judge on Trump shortlist boasts stint on Michigan's high court Conservatives see Kethledge as 'Gorsuch 2.0' MORE (D-Mich.) offered an amendment that would prevent Medicare from becoming a voucher program. Her amendment received a 96-3 vote.

Cruz, Lee and Paul voted against Stabenow's amendment.

“I am proud that the Senate Budget preserves and protects Medicare for seniors today and in the future," Murray said. “Medicare is vital to the health and well being of more than 50 million seniors and Americans with disabilities."

The Senate reached a deal to hold five amendment votes Thursday night and will vote on six more amendments Friday morning at 11 a.m., while the 50 hours of required debate continues. Debate time could be yielded back in order to start the "vote-a-rama" on an unlimited number of germane amendments before 7 p.m. Friday.

—This article was updated at 9:38 p.m. to include Rep. Nancy Pelosi's (D-Calif.) statement.