“ObamaCare was passed with many promises, and in reality, it has not delivered,” Cruz said ahead of the vote. “ObamaCare is hurting young people, it’s hurting seniors, it’s hurting Hispanics, it’s hurting African-Americans, it’s hurting the economy and it should be repealed."

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The Senate is considering Budget Committee Chairwoman Patty MurrayPatricia (Patty) Lynn MurrayWeek ahead: Senators near deal to stabilize ObamaCare markets Policymaking commission offers a glimmer of hope in hyper-partisan Washington Dems call on DeVos to work with CFPB to protect student borrowers MORE’s (D-Wash.) budget, which would reduce the deficit by $1.85 trillion over 10 years through an equal amount of spending reductions and revenue increases.

House Budget Committee Chairman Paul RyanPaul RyanRyan: Graham-Cassidy 'best, last chance' to repeal ObamaCare Ryan: Americans want to see Trump talking with Dem leaders Overnight Finance: CBO to release limited analysis of ObamaCare repeal bill | DOJ investigates Equifax stock sales | House weighs tougher rules for banks dealing with North Korea MORE’s (R-Wis.) plan balances the budget in 10 years through $5.7 trillion in projected spending reductions. Democrats criticize his plan because he repeals the Affordable Care Act and would turn Medicare into a voucher system.

“The Senate budget commits to ensuring the full implementation of the Affordable Care Act, so that we can continue building a stronger and more sustainable healthcare system for all Americans,” Murray said. “Unfortunately, the House Republican budget would do the opposite.”

Republicans say Obama’s signature healthcare law hurts the economy and raises taxes on the public and businesses.

The Senate also rejected an amendment from Sen. Mike CrapoMichael (Mike) Dean CrapoSenate Banking panel approves Trump's Fed, comptroller nominees Harvey damage adds urgency to flood insurance debate Don't let funding for US Forest Service go up in flames MORE (R-Idaho), which would have repealed the tax increases on individuals from the Affordable Care Act. Crapo’s amendment was rejected on a 45-54 vote Friday.

“ObamaCare itself includes some 20 tax increases over $1 trillion,” Cruz said. “Many of those tax increases fall of the middle class.”

But some healthcare related amendments succeeded. On Friday, the Senate accepted Sen. Jeanne ShaheenCynthia (Jeanne) Jeanne ShaheenWeek ahead: Crunch time for defense bill’s cyber reforms | Equifax under scrutiny Five things to know about the Kaspersky-Russia controversy DHS bans Kaspersky software in federal agencies MORE’s (D-N.H.) amendment to protect women’s healthcare coverage and employer-provided contraceptive coverage authorized under the Affordable Care Act. That amendment passed on a 56-43 vote.

Some Republicans argue that employers shouldn’t have to fund contraception if they disagree with it for moral and religious reasons.

"We must also protect the deeply religious beliefs in this country," Sen. Mike JohannsMike JohannsLobbying World To buy a Swiss company, ChemChina must pass through Washington Republican senator vows to block nominees over ObamaCare co-ops MORE (R-Neb.) said. "This law tramples on the rights of individuals." 

Shaheen said that her amendment makes sure a woman’s family planning decisions “are not dictated by government or her employer.”

“The United States has one of the highest rate of unintended pregnancies in the developed world,” Shaheen said. “Preventing unintended pregnancies just makes sense.”

GOP Sens. Susan CollinsSusan Margaret CollinsSenate Dems hold floor talk-a-thon against latest ObamaCare repeal bill Ryan: Graham-Cassidy 'best, last chance' to repeal ObamaCare Collins skeptical of new ObamaCare repeal effort MORE (Maine), Mark KirkMark KirkStale, misguided, divisive: minimum wage can't win elections Immigration critics find their champion in Trump Trump's nominee to lead USAID has the right philosophy on international aid MORE (Ill.) and Lisa MurkowskiLisa Ann MurkowskiSenate Dems hold floor talk-a-thon against latest ObamaCare repeal bill Collins skeptical of new ObamaCare repeal effort How Senate relationships could decide ObamaCare repeal MORE (Alaska) voted with most Democrats — Sen. Joe ManchinJoseph (Joe) ManchinGOP sees fresh opening with Dems’ single payer embrace Trump steps up courtship of Dems The Hill's 12:30 Report MORE (D-W.V.a) was the only Democrat to vote against Shaheen's amendment.

On Thursday night, senators voted 79-20 to repeal a 2.3 percent medical device tax, which was enacted as part of Obama’s healthcare law. Sen. Orrin HatchOrrin Grant HatchFinance to hold hearing on ObamaCare repeal bill Overnight Finance: CBO to release limited analysis of ObamaCare repeal bill | DOJ investigates Equifax stock sales | House weighs tougher rules for banks dealing with North Korea Week ahead in finance: Clock ticking for GOP on tax reform MORE (R-Utah) introduced that amendment.

The Senate will continue debate on the budget until about 3 p.m. Friday. Then it will have a "vote-a-rama" on an unlimited number of germane amendments until final passage.

Murray’s budget includes $100 billion in stimulus funding that Democrats say will help economic growth and workforce training. 

Republicans have said the budget overestimates the extent to which it would reduce the deficit, and raises $1 trillion in new taxes. Democrats say their budget cuts the deficit by $1.85 trillion over 10 years through an equal amount of spending cuts and new revenue, but the GOP has said that because it assumes the sequester will not happen, the amount of deficit reduction is closer to $700 billion.

This article was updated at 12:30 p.m. to include the votes on Shaheen and Crapo's amendments.