“ObamaCare was passed with many promises, and in reality, it has not delivered,” Cruz said ahead of the vote. “ObamaCare is hurting young people, it’s hurting seniors, it’s hurting Hispanics, it’s hurting African-Americans, it’s hurting the economy and it should be repealed."

The Senate is considering Budget Committee Chairwoman Patty MurrayPatty MurrayLawmakers send McCain well wishes after cancer diagnosis Trump labor board nominees advance in Senate Dems tout failure of GOP healthcare bill MORE’s (D-Wash.) budget, which would reduce the deficit by $1.85 trillion over 10 years through an equal amount of spending reductions and revenue increases.

House Budget Committee Chairman Paul RyanPaul RyanRyan: CBO's healthcare estimate is 'bogus' Kushner speech to congressional interns delayed Overnight Energy: Exxon sues feds over M sanctions fine MORE’s (R-Wis.) plan balances the budget in 10 years through $5.7 trillion in projected spending reductions. Democrats criticize his plan because he repeals the Affordable Care Act and would turn Medicare into a voucher system.

“The Senate budget commits to ensuring the full implementation of the Affordable Care Act, so that we can continue building a stronger and more sustainable healthcare system for all Americans,” Murray said. “Unfortunately, the House Republican budget would do the opposite.”

Republicans say Obama’s signature healthcare law hurts the economy and raises taxes on the public and businesses.

The Senate also rejected an amendment from Sen. Mike CrapoMike CrapoGOP lawmakers introduce measures to repeal consumer bureau arbitration rule Senate Banking leaders introduce flood insurance bill Overnight Regulation: Senate Banking panel huddles with regulators on bank relief | FCC proposes 2M fine on robocaller | Yellowstone grizzly loses endangered protection MORE (R-Idaho), which would have repealed the tax increases on individuals from the Affordable Care Act. Crapo’s amendment was rejected on a 45-54 vote Friday.

“ObamaCare itself includes some 20 tax increases over $1 trillion,” Cruz said. “Many of those tax increases fall of the middle class.”

But some healthcare related amendments succeeded. On Friday, the Senate accepted Sen. Jeanne Shaheen Jeanne ShaheenOvernight Defense: Trump gets briefing at Pentagon on ISIS, Afghanistan | Senate panel approves five defense picks | Senators want Syria study in defense bill Gore wishes Mikulski a happy birthday at 'Inconvenient Sequel' premiere Senators ask for Syria policy study in defense bill MORE’s (D-N.H.) amendment to protect women’s healthcare coverage and employer-provided contraceptive coverage authorized under the Affordable Care Act. That amendment passed on a 56-43 vote.

Some Republicans argue that employers shouldn’t have to fund contraception if they disagree with it for moral and religious reasons.

"We must also protect the deeply religious beliefs in this country," Sen. Mike JohannsMike JohannsLobbying World To buy a Swiss company, ChemChina must pass through Washington Republican senator vows to block nominees over ObamaCare co-ops MORE (R-Neb.) said. "This law tramples on the rights of individuals." 

Shaheen said that her amendment makes sure a woman’s family planning decisions “are not dictated by government or her employer.”

“The United States has one of the highest rate of unintended pregnancies in the developed world,” Shaheen said. “Preventing unintended pregnancies just makes sense.”

GOP Sens. Susan CollinsSusan CollinsOPINION | GOP healthcare attack is a vendetta against President Obama Rand Paul opens door to backing healthcare bill on key hurdle The Memo: Trump tries to bend Congress to his will MORE (Maine), Mark KirkMark KirkMcConnell: Senate to try to repeal ObamaCare next week GOP senator: Not 'appropriate' to repeal ObamaCare without replacement GOP's repeal-only plan quickly collapses in Senate MORE (Ill.) and Lisa MurkowskiLisa MurkowskiOPINION | GOP healthcare attack is a vendetta against President Obama Conservative group to give GOP healthcare holdouts ‘Freedom Traitors Award’ Source: Senate leaders to offer 0 billion to win over moderates MORE (Alaska) voted with most Democrats — Sen. Joe ManchinJoe ManchinGovernors-turned-senators meet to talk healthcare Manchin organizing bipartisan healthcare meeting Tuesday night Moderate Republicans, Dems huddle on healthcare MORE (D-W.V.a) was the only Democrat to vote against Shaheen's amendment.

On Thursday night, senators voted 79-20 to repeal a 2.3 percent medical device tax, which was enacted as part of Obama’s healthcare law. Sen. Orrin HatchOrrin HatchSenate panel advances Trump's tax policy nominee Healthcare debacle raises pressure for GOP on taxes GOP frets over stalled agenda MORE (R-Utah) introduced that amendment.

The Senate will continue debate on the budget until about 3 p.m. Friday. Then it will have a "vote-a-rama" on an unlimited number of germane amendments until final passage.

Murray’s budget includes $100 billion in stimulus funding that Democrats say will help economic growth and workforce training. 

Republicans have said the budget overestimates the extent to which it would reduce the deficit, and raises $1 trillion in new taxes. Democrats say their budget cuts the deficit by $1.85 trillion over 10 years through an equal amount of spending cuts and new revenue, but the GOP has said that because it assumes the sequester will not happen, the amount of deficit reduction is closer to $700 billion.

This article was updated at 12:30 p.m. to include the votes on Shaheen and Crapo's amendments.