“ObamaCare was passed with many promises, and in reality, it has not delivered,” Cruz said ahead of the vote. “ObamaCare is hurting young people, it’s hurting seniors, it’s hurting Hispanics, it’s hurting African-Americans, it’s hurting the economy and it should be repealed."

The Senate is considering Budget Committee Chairwoman Patty MurrayPatricia (Patty) Lynn MurrayDemocrats turn on Al Franken VA slashes program that helps homeless veterans obtain housing: report The Hill's 12:30 Report MORE’s (D-Wash.) budget, which would reduce the deficit by $1.85 trillion over 10 years through an equal amount of spending reductions and revenue increases.

House Budget Committee Chairman Paul RyanPaul Davis RyanMcConnell names Senate GOP tax conferees House Republican: 'I worry about both sides' of the aisle on DACA Overnight Health Care: 3.6M signed up for ObamaCare in first month | Ryan pledges 'entitlement reform' next year | Dems push for more money to fight opioids MORE’s (R-Wis.) plan balances the budget in 10 years through $5.7 trillion in projected spending reductions. Democrats criticize his plan because he repeals the Affordable Care Act and would turn Medicare into a voucher system.

“The Senate budget commits to ensuring the full implementation of the Affordable Care Act, so that we can continue building a stronger and more sustainable healthcare system for all Americans,” Murray said. “Unfortunately, the House Republican budget would do the opposite.”

Republicans say Obama’s signature healthcare law hurts the economy and raises taxes on the public and businesses.

The Senate also rejected an amendment from Sen. Mike CrapoMichael (Mike) Dean CrapoOvernight Regulation: Feds push to clarify regs on bump stocks | Interior wants Trump to shrink two more monuments | Navajo Nation sues over monument rollback | FCC won't delay net neutrality vote | Senate panel approves bill easing Dodd-Frank rules Overnight Finance: GOP delays work on funding bill amid conservative demands | Senate panel approves Fed nominee Powell | Dodd-Frank rollback advances | WH disputes report Mueller subpoenaed Trump bank records Senate panel moves forward with bill to roll back Dodd-Frank MORE (R-Idaho), which would have repealed the tax increases on individuals from the Affordable Care Act. Crapo’s amendment was rejected on a 45-54 vote Friday.

“ObamaCare itself includes some 20 tax increases over $1 trillion,” Cruz said. “Many of those tax increases fall of the middle class.”

But some healthcare related amendments succeeded. On Friday, the Senate accepted Sen. Jeanne ShaheenCynthia (Jeanne) Jeanne ShaheenDems demand Tillerson end State hiring freeze, consult with Congress The Hill Interview: GOP chairman says ‘red flags’ surround Russian cyber firm Schumer celebrates New York Giants firing head coach: ‘About time’ MORE’s (D-N.H.) amendment to protect women’s healthcare coverage and employer-provided contraceptive coverage authorized under the Affordable Care Act. That amendment passed on a 56-43 vote.

Some Republicans argue that employers shouldn’t have to fund contraception if they disagree with it for moral and religious reasons.

"We must also protect the deeply religious beliefs in this country," Sen. Mike JohannsMike JohannsFarmers, tax incentives can ease the pain of a smaller farm bill Lobbying World To buy a Swiss company, ChemChina must pass through Washington MORE (R-Neb.) said. "This law tramples on the rights of individuals." 

Shaheen said that her amendment makes sure a woman’s family planning decisions “are not dictated by government or her employer.”

“The United States has one of the highest rate of unintended pregnancies in the developed world,” Shaheen said. “Preventing unintended pregnancies just makes sense.”

GOP Sens. Susan CollinsSusan Margaret CollinsOvernight Health Care: 3.6M signed up for ObamaCare in first month | Ryan pledges 'entitlement reform' next year | Dems push for more money to fight opioids Study: ObamaCare bills backed by Collins would lower premiums Right scrambles GOP budget strategy MORE (Maine), Mark KirkMark KirkHigh stakes as Trump heads to Hill Five things to watch for at Trump-Senate GOP meeting Giffords, Scalise highlight party differences on guns MORE (Ill.) and Lisa MurkowskiLisa Ann MurkowskiMcConnell names Senate GOP tax conferees Week ahead: Trump expected to shrink two national monuments GOP on verge of opening Arctic refuge to drilling MORE (Alaska) voted with most Democrats — Sen. Joe ManchinJoseph (Joe) ManchinTrump rips Dems a day ahead of key White House meeting Senate panel moves forward with bill to roll back Dodd-Frank Wealthy outsiders threaten to shake up GOP Senate primaries MORE (D-W.V.a) was the only Democrat to vote against Shaheen's amendment.

On Thursday night, senators voted 79-20 to repeal a 2.3 percent medical device tax, which was enacted as part of Obama’s healthcare law. Sen. Orrin HatchOrrin Grant HatchMcConnell names Senate GOP tax conferees Ryan pledges 'entitlement reform' in 2018 Utah governor calls Bannon a 'bigot' after attacks on Romney MORE (R-Utah) introduced that amendment.

The Senate will continue debate on the budget until about 3 p.m. Friday. Then it will have a "vote-a-rama" on an unlimited number of germane amendments until final passage.

Murray’s budget includes $100 billion in stimulus funding that Democrats say will help economic growth and workforce training. 

Republicans have said the budget overestimates the extent to which it would reduce the deficit, and raises $1 trillion in new taxes. Democrats say their budget cuts the deficit by $1.85 trillion over 10 years through an equal amount of spending cuts and new revenue, but the GOP has said that because it assumes the sequester will not happen, the amount of deficit reduction is closer to $700 billion.

This article was updated at 12:30 p.m. to include the votes on Shaheen and Crapo's amendments.