The Senate voted 96-0 to confirm the nomination of Sylvia BurwellSylvia Mary Mathews BurwellPrice was a disaster for HHS — Time for an administrator, not an ideologue Overnight Healthcare: GOP chairman to introduce pre-existing condition bill ObamaCare enrollment hits 11.5M for 2017 MORE to serve as director of the Office of Management and Budget.

The vote Wednesday means that Burwell will officially replace Jacob Lew, who resigned from the OMB post to serve as Secretary of the Treasury earlier this year.

President Obama hailed the unanimous confirmation vote and said Burwell will be instrumental in turning off the spending cuts from sequestration that have been blamed this week for long delays at airports. 

"Sylvia has spent a career fighting for working families, and she was part of an OMB team that presided over three budget surpluses in a row. Her experience will be especially important as we continue our efforts to replace the indiscriminate budget cuts that are already starting to cost jobs, hurt families, and inconvenience Americans," Obama said.

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Senate Budget Committee Chairwoman Patty MurrayPatricia (Patty) Lynn MurrayLawmakers eye retirement help for gig economy workers Overnight Regulation: Labor Department reportedly hid unfavorable report on tip-pooling rule | NY plans to sue EPA over water rule | Senators urge FTC to probe company selling fake Twitter followers Trump's vows to take on drug prices, opioids draw skepticism MORE (D-Wash.) said Burwell’s nomination comes at a critical time for the nation’s economy.

“[Burwell] knows budgets are a reflection of our values and priorities,” Murray said ahead of the vote Wednesday. “She knows that working to find common ground is key to solving our country's economic challenges.”

The Budget Committee cleared Burwell’s nomination with unanimous support this month.

Prior to her nomination, Burwell served as president of the Walmart Foundation and before that was president of the Global Development Program of the Bill and Melinda Gates Foundation. She also worked as deputy White House budget director during the Clinton administration.

Sen. Joe ManchinJoseph (Joe) ManchinMcConnell: 'Whoever gets to 60 wins' on immigration Manchin: Senators should sign pledge not to campaign against each other  GOP senators turning Trump immigration framework into legislation MORE (D-W.Va.) said he supported Burwell’s nomination not just because she was from his home state, but because she embodies what’s great about America.

“She’s spent most of her life trying to help American families achieve the American dream,” Manchin said.

The Senate also confirmed the judicial nomination of Jane Kelly to be a U.S. Circuit Judge for the Eighth Circuit. She was confirmed on an 96-0 vote Wednesday afternoon.

“She is well regarded in my home state of Iowa,” Senate Judiciary Committee ranking member Chuck GrassleyCharles (Chuck) Ernest GrassleyOvernight Cybersecurity: Tillerson proposes new cyber bureau at State | Senate bill would clarify cross-border data rules | Uber exec says 'no justification' for covering up breach Overnight Finance: Senators near two-year budget deal | Trump would 'love to see a shutdown' over immigration | Dow closes nearly 600 points higher after volatile day | Trade deficit at highest level since 2008 | Pawlenty leaving Wall Street group Grassley to Sessions: Policy for employees does not comply with the law MORE (R-Iowa) said. “So I’m pleased to support the nomination of Ms. Kelly.”

Sen. Tom HarkinThomas (Tom) Richard HarkinOrrin Hatch, ‘a tough old bird,’ got a lot done in the Senate Democrats are all talk when it comes to DC statehood The Hill's 12:30 Report MORE (D-Iowa) said Kelly has the qualifications necessary to perform the duties of an appellate court judge because she has a “deep sense of compassion and fairness.”

—Updated at 1:48 p.m.