“We have not had a confirmed administrator since 2006,” Sen. Tim KaineTimothy Michael KaineWake up, Republicans, touting Trumpism is a losing strategy GOP feels pressure to deliver after election rout Dems mull big changes after Brazile bombshell MORE (D-Va.) said ahead of the vote. “It will be a good thing for the mission and the country to confirm an administrator.”

Republican Sens. Ted CruzRafael (Ted) Edward CruzOvernight Finance: GOP criticism of tax bill grows, but few no votes | Highlights from day two of markup | House votes to overturn joint-employer rule | Senate panel approves North Korean banking sanctions GOP criticism of tax bill grows, but few ready to vote against it Anti-gay marriage county clerk Kim Davis to seek reelection in Kentucky MORE (Texas), Ron JohnsonRonald (Ron) Harold JohnsonDemocratic Homeland Security members request additional DHS nominee testimony Key differences between the Senate and House tax plans Senate panel delays vote on Trump’s Homeland Security pick MORE (Wis.), Mike LeeMichael (Mike) Shumway LeeOvernight Health Care: Trump officials to allow work requirements for Medicaid GOP senator: CBO moving the goalposts on ObamaCare mandate Cornyn: Senate GOP tax plan to be released Thursday MORE (Utah), Mike CrapoMichael (Mike) Dean CrapoOvernight Finance: GOP criticism of tax bill grows, but few no votes | Highlights from day two of markup | House votes to overturn joint-employer rule | Senate panel approves North Korean banking sanctions Senate panel approves North Korea banking sanctions Trump names Powell as chairman of Federal Reserve MORE (Idaho), James Risch (Idaho), Mitch McConnellAddison (Mitch) Mitchell McConnellMcConnell expects Paul to return to Senate next week Former Hill staff calls for mandatory harassment training Gaming the odds of any GOP tax bill getting signed into law MORE and Rand PaulRandal (Rand) Howard PaulGOP senator asks to be taken off Moore fundraising appeals Red state lawmakers find blue state piggy bank Prosecutors tell Paul to expect federal charges against attacker: report MORE (Ky.) voted against Tavenner's nominations.

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Sen. Tom HarkinTom HarkinThe Hill's 12:30 Report Distance education: Tumultuous today and yesterday Grassley challenger no stranger to defying odds MORE (D-Iowa) had placed a hold on her nomination out of frustration with the administration’s plan to spend prevention funds on promotions for the Affordable Care Act. He lifted the hold earlier this month after he said enough light had been shined on the issue.

CMS administers the Medicare and Medicaid programs and is also charged with implementing most of Obama's healthcare law. Tavenner has been leading CMS on an acting basis.

Kaine said Tavenner, who is from Virginia, was the right pick because she would bring a patient-focused “nurse’s attitude” to CMS and she is an “expert” on finding healthcare cost savings.

Before the vote on Tavenner, the Senate also voted to approve the nomination of William Orrick to be U.S. District Judge for the Northern District of California. He was confirmed on a 56-41 vote.

Sen. Barbara BoxerBarbara BoxerFour more lawmakers say they’ve been sexually harassed by colleagues in Congress California Hispanics are the vanguard for a new political paradigm Trump riles Dems with pick for powerful EPA job MORE (D-Calif.) said she was glad Orrick got a vote because the Northern District of California has a judicial emergency with a caseload 24 percent higher than the national average.

“We all know justice delayed is justice denied,” Boxer said. “That’s why I’m excited we’re finally getting a vote on this nominee.”

Sen. Chuck GrassleyCharles (Chuck) Ernest GrassleySenators push mandatory sexual harassment training for members, staff Senate panel to hold hearing on bump stocks, background checks Senate panel to hold hearing on bump stocks MORE (R-Iowa) said he opposed Orrick's nomination because he  didn't like a judicial decision he made that maintained the “weak status quo” of immigration and border enforcement. He added that Orrick didn't answer all of his questions during his confirmation hearing with the Judiciary Committee, where Grassley serves as the ranking member.