“We have not had a confirmed administrator since 2006,” Sen. Tim KaineTim KaineLive coverage: Senate Dems hold talkathon to protest GOP health plan Trump supporter who lost tight Va. governor primary weighs Senate run Northam defeats Sanders-backed candidate in Va. gov primary MORE (D-Va.) said ahead of the vote. “It will be a good thing for the mission and the country to confirm an administrator.”

Republican Sens. Ted CruzTed CruzSenate Republicans reluctant to rush vote on healthcare bill Healthcare bill 'not the last step' to repealing ObamaCare, Republican says Dem senator: GOP's healthcare approach will 'devastate Medicaid' MORE (Texas), Ron JohnsonRon JohnsonSenate Republicans reluctant to rush vote on healthcare bill GOP sen: 'We should not be voting' on healthcare this week GOP at decisive moment on Planned Parenthood MORE (Wis.), Mike LeeMike LeeSenate Republicans reluctant to rush vote on healthcare bill Time to get Trump’s new antitrust cop on the beat GOP at decisive moment on Planned Parenthood MORE (Utah), Mike CrapoMike CrapoOvernight Regulation: Senate Banking panel huddles with regulators on bank relief | FCC proposes 2M fine on robocaller | Yellowstone grizzly loses endangered protection Overnight Finance: Big US banks pass Fed stress tests | Senate bill repeals most ObamaCare taxes | Senate expected to pass Russian sanctions bill for second time All big US banks pass Dodd-Frank stress tests MORE (Idaho), James Risch (Idaho), Mitch McConnellMitch McConnellCornyn: Passing Senate healthcare bill by July 4 ‘optimistic’ Sasse has 'nothing to announce' on GOP ObamaCare repeal Price: 'No guarantees' people won't fall through cracks of healthcare bill MORE and Rand PaulRand PaulSenate Republicans reluctant to rush vote on healthcare bill Healthcare bill 'not the last step' to repealing ObamaCare, Republican says Rand Paul: 'If you offer me a 90 percent repeal, I'd probably vote for it' MORE (Ky.) voted against Tavenner's nominations.

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Sen. Tom HarkinTom HarkinDistance education: Tumultuous today and yesterday Grassley challenger no stranger to defying odds Clinton ally stands between Sanders and chairmanship dream MORE (D-Iowa) had placed a hold on her nomination out of frustration with the administration’s plan to spend prevention funds on promotions for the Affordable Care Act. He lifted the hold earlier this month after he said enough light had been shined on the issue.

CMS administers the Medicare and Medicaid programs and is also charged with implementing most of Obama's healthcare law. Tavenner has been leading CMS on an acting basis.

Kaine said Tavenner, who is from Virginia, was the right pick because she would bring a patient-focused “nurse’s attitude” to CMS and she is an “expert” on finding healthcare cost savings.

Before the vote on Tavenner, the Senate also voted to approve the nomination of William Orrick to be U.S. District Judge for the Northern District of California. He was confirmed on a 56-41 vote.

Sen. Barbara BoxerBarbara BoxerTime is now to address infrastructure needs Tom Steyer testing waters for Calif. gubernatorial bid Another day, another dollar for retirement advice rip-offs MORE (D-Calif.) said she was glad Orrick got a vote because the Northern District of California has a judicial emergency with a caseload 24 percent higher than the national average.

“We all know justice delayed is justice denied,” Boxer said. “That’s why I’m excited we’re finally getting a vote on this nominee.”

Sen. Chuck GrassleyChuck GrassleySenate panel questions Lynch on alleged FBI interference The Hill's 12:30 Report GOP senator surprises top Dem with birthday cake MORE (R-Iowa) said he opposed Orrick's nomination because he  didn't like a judicial decision he made that maintained the “weak status quo” of immigration and border enforcement. He added that Orrick didn't answer all of his questions during his confirmation hearing with the Judiciary Committee, where Grassley serves as the ranking member.