“We have not had a confirmed administrator since 2006,” Sen. Tim KaineTim Kaine Violent white nationalist protests prompt state of emergency in Virginia Republicans will get their comeuppance in New Jersey, Virginia Spicer signs deal with top TV lawyer: report MORE (D-Va.) said ahead of the vote. “It will be a good thing for the mission and the country to confirm an administrator.”

Republican Sens. Ted CruzTed CruzThe media couldn't be more blatant in distorting Trump's words on Charlottesville Curtis wins GOP primary for House seat vacated by Jason Chaffetz Kimmel: Let’s make Trump a king so he has no power MORE (Texas), Ron JohnsonRon JohnsonCEOs revolt against Trump over Charlottesville GOP senator: Trump hasn't 'changed much' since campaign Senators push for possible FCC enforcement over Lifeline fraud MORE (Wis.), Mike LeeMike LeeTrouble draining the swamp? Try returning power to the states Congress must act to protect data privacy before courts make surveillance even easier Five tough decisions for the GOP on healthcare MORE (Utah), Mike CrapoMike CrapoYou're fired! Why it's time to ditch the Fed's community banker seat GOP debates tax cuts vs. tax reform Conservative groups urge Trump to stick with Ex-Im Bank nominee MORE (Idaho), James Risch (Idaho), Mitch McConnellMitch McConnellTrump’s isolation grows Ellison: Trump has 'level of sympathy' for neo-Nazis, white supremacists Trump touts endorsement of second-place finisher in Alabama primary MORE and Rand PaulRand PaulCurtis wins GOP primary for House seat vacated by Jason Chaffetz Glimmer of hope in bipartisan criminal justice reform effort Trump barrage stuns McConnell and his allies MORE (Ky.) voted against Tavenner's nominations.

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Sen. Tom HarkinTom HarkinDistance education: Tumultuous today and yesterday Grassley challenger no stranger to defying odds Clinton ally stands between Sanders and chairmanship dream MORE (D-Iowa) had placed a hold on her nomination out of frustration with the administration’s plan to spend prevention funds on promotions for the Affordable Care Act. He lifted the hold earlier this month after he said enough light had been shined on the issue.

CMS administers the Medicare and Medicaid programs and is also charged with implementing most of Obama's healthcare law. Tavenner has been leading CMS on an acting basis.

Kaine said Tavenner, who is from Virginia, was the right pick because she would bring a patient-focused “nurse’s attitude” to CMS and she is an “expert” on finding healthcare cost savings.

Before the vote on Tavenner, the Senate also voted to approve the nomination of William Orrick to be U.S. District Judge for the Northern District of California. He was confirmed on a 56-41 vote.

Sen. Barbara BoxerBarbara BoxerTime is now to address infrastructure needs Tom Steyer testing waters for Calif. gubernatorial bid Another day, another dollar for retirement advice rip-offs MORE (D-Calif.) said she was glad Orrick got a vote because the Northern District of California has a judicial emergency with a caseload 24 percent higher than the national average.

“We all know justice delayed is justice denied,” Boxer said. “That’s why I’m excited we’re finally getting a vote on this nominee.”

Sen. Chuck GrassleyChuck GrassleyWhite House clarifies: We condemn all violence Republican lawmakers criticize Trump response to Charlottesville Grassley reverses ‘expectation’ of Supreme Court vacancy this year MORE (R-Iowa) said he opposed Orrick's nomination because he  didn't like a judicial decision he made that maintained the “weak status quo” of immigration and border enforcement. He added that Orrick didn't answer all of his questions during his confirmation hearing with the Judiciary Committee, where Grassley serves as the ranking member.