“We have not had a confirmed administrator since 2006,” Sen. Tim KaineTimothy (Tim) Michael KaineSenate campaign fundraising reports roll in Afghanistan moves reignite war authorization debate Ralph Northam sworn in as Virginia governor MORE (D-Va.) said ahead of the vote. “It will be a good thing for the mission and the country to confirm an administrator.”

Republican Sens. Ted CruzRafael (Ted) Edward CruzWith religious liberty memo, Trump made America free to be faithful again Interstate compacts aren't the right way to fix occupational licensing laws Texas Dem: ‘I don’t know what to believe’ about what Trump wants for wall MORE (Texas), Ron JohnsonRonald (Ron) Harold JohnsonGOP senators eager for Romney to join them The House needs to help patients from being victimized by antiquated technology Comey’s original Clinton memo released, cites possible violations MORE (Wis.), Mike LeeMichael (Mike) Shumway LeeNSA spying program overcomes key Senate hurdle With religious liberty memo, Trump made America free to be faithful again This week: Time running out for Congress to avoid shutdown MORE (Utah), Mike CrapoMichael (Mike) Dean CrapoTrump calls for looser rules for bank loans in Dodd-Frank overhaul Week ahead: Lawmakers eye another short-term spending bill Overnight Finance: Trump promises farmers 'better deal' on NAFTA | Clock ticks to shutdown deadline | Dems worry Trump pressuring IRS on withholdings | SEC halts trading in digital currency firm MORE (Idaho), James Risch (Idaho), Mitch McConnellAddison (Mitch) Mitchell McConnellSessions: 'We should be like Canada' in how we take in immigrants NSA spying program overcomes key Senate hurdle Overnight Finance: Lawmakers see shutdown odds rising | Trump calls for looser rules for bank loans | Consumer bureau moves to revise payday lending rule | Trump warns China on trade deficit MORE and Rand PaulRandal (Rand) Howard PaulNSA spying program overcomes key Senate hurdle Fix what we’ve got and make Medicare right this year Despite amnesty, DACA bill favors American wage-earners MORE (Ky.) voted against Tavenner's nominations.

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Sen. Tom HarkinThomas (Tom) Richard HarkinOrrin Hatch, ‘a tough old bird,’ got a lot done in the Senate Democrats are all talk when it comes to DC statehood The Hill's 12:30 Report MORE (D-Iowa) had placed a hold on her nomination out of frustration with the administration’s plan to spend prevention funds on promotions for the Affordable Care Act. He lifted the hold earlier this month after he said enough light had been shined on the issue.

CMS administers the Medicare and Medicaid programs and is also charged with implementing most of Obama's healthcare law. Tavenner has been leading CMS on an acting basis.

Kaine said Tavenner, who is from Virginia, was the right pick because she would bring a patient-focused “nurse’s attitude” to CMS and she is an “expert” on finding healthcare cost savings.

Before the vote on Tavenner, the Senate also voted to approve the nomination of William Orrick to be U.S. District Judge for the Northern District of California. He was confirmed on a 56-41 vote.

Sen. Barbara BoxerBarbara Levy BoxerDems face hard choice for State of the Union response Billionaire Steyer to push for Dem House push Billionaire Steyer announces million for Dem House push MORE (D-Calif.) said she was glad Orrick got a vote because the Northern District of California has a judicial emergency with a caseload 24 percent higher than the national average.

“We all know justice delayed is justice denied,” Boxer said. “That’s why I’m excited we’re finally getting a vote on this nominee.”

Sen. Chuck GrassleyCharles (Chuck) Ernest GrassleyGOP senators eager for Romney to join them Five hurdles to a big DACA and border deal Grand jury indicts Maryland executive in Uranium One deal: report MORE (R-Iowa) said he opposed Orrick's nomination because he  didn't like a judicial decision he made that maintained the “weak status quo” of immigration and border enforcement. He added that Orrick didn't answer all of his questions during his confirmation hearing with the Judiciary Committee, where Grassley serves as the ranking member.