GOP members of the Gang of Eight — Sens. John McCainJohn McCainKeith Ellison on McCain’s vote: How many others with brain cancer will lose coverage? McCain votes to advance ObamaCare repeal, replace after vowing to oppose Overnight Defense: House passes Russia sanctions deal | McCain returns to Senate | Watchdog opens criminal probe into M camo mistake MORE (Ariz.), Lindsey GrahamLindsey GrahamSenate rejects ObamaCare repeal, replacement amendment Trump turns up heat on AG Sessions over recusal OPINION | McConnell attempt to butcher ObamaCare is political malpractice MORE (S.C.), Jeff FlakeJeff FlakeOPINION | Healthcare vote a political death wish for GOP in 2018 Flake secretly wrote book on conservative politics: report Dem campaign arm slams Heller, Flake on healthcare votes MORE (Ariz.) and Marco RubioMarco RubioMexican politicians have a new piñata: Donald Trump Bush ethics lawyer: Congress must tell Trump not to fire Mueller The private alternative to the National Flood Insurance Program  MORE (Fla.) — voted against Lee's amendment, along with Republican Sens. Lisa MurkowskiLisa MurkowskiScaramucci: 'I'm more of a front-stabbing person' compared to D.C. backstabbers Trump targets Murkowski after healthcare votes Warren: Entire country must speak up on GOP healthcare bill MORE (Alaska) and Susan CollinsSusan CollinsTrump targets Murkowski after healthcare votes Warren: Entire country must speak up on GOP healthcare bill Senate rejects ObamaCare repeal, replacement amendment MORE (Maine).

Lee’s amendment would have required fast-track congressional approval when the Secretary of Homeland Security notified Congress of the full implementation of the border security strategies and operations.

“Congress must be able to vote on the border enforcement strategy,” Lee said ahead of the vote. “To cut Congress out cuts out the American people.”

Lee argued that a fast-track vote would allow the Senate to vote with a majority threshold on whether the Department of Homeland Security is keeping its promises before allowing immigrants to start the pathway to citizenship.

Senate Judiciary Committee Chairman Patrick LeahyPatrick LeahySenate committee ignores Trump, House budgets in favor of 2017 funding levels Live coverage: Trump's FBI nominee questioned by senators AT&T, senators spar over customers' right to sue MORE (D-Vt.) urged his colleagues to oppose Lee's amendment because it would "delay" the pathway to citizenship.

The Senate is considering the Border Security, Economic Opportunity and Immigration Modernization Act. Amendment work on the bill is expected throughout the week.

The bipartisan group of eight senators, known as the Gang of Eight, introduced S. 744, which would create a pathway to citizenship for illegal immigrants already in the country, toughen border security, create a guest-worker program and boost high-skilled immigration.

Republicans have argued that the Gang of Eight bill grants amnesty to 11 million immigrants in the country illegally before implementing border security measures, repeating the mistakes made in the last major immigration reform in 1986.

GOP senators have demanded that the bill include border security triggers in order for them to support the legislation.

Those supporting the bill say it appropriates an additional $6.5 billion for border enforcement measures.

The bill also makes permanent legal residence contingent on the Department of Homeland Security having 100 percent situational awareness at every segment of the Southern border and a 90 percent apprehension rate of those illegally crossing. But some Republicans have suggested that the bill gives the department too much say over whether the border is secure, leaving Congress powerless to stop the amnesty program if security measures aren’t met.

On Wednesday, the Senate voted on other amendments, all of which were held to a 60-vote threshold.

Sen. Jeff MerkleyJeff MerkleyOPINION | Shailene Woodley: US should run on renewable energy by 2050 Gore wishes Mikulski a happy birthday at 'Inconvenient Sequel' premiere Callista Gingrich touts Trump's commitment to environment despite Paris deal pullout MORE’s (D-Ore.) amendment passed by voice vote. It increases requires state workforce agencies to certify that employers are actively recruiting Americans and that Americans are not qualified or available to fill the positions that the employer wants to fill with H-2B visas.

Sen. Joe ManchinJoe ManchinManchin on GOP lawmaker’s suggestion for a duel with female senators: I’ll ‘step outside with him’ McCain returning to Senate in time for health vote Pressure on Trump grows as Kushner is questioned MORE’s (D-W.Va.) amendment caps border security contractors' salaries at $230,700 a year, and was approved on a 72-26 vote.

Sen. Mark PryorMark PryorMedicaid rollback looms for GOP senators in 2020 Cotton pitches anti-Democrat message to SC delegation Ex-Sen. Kay Hagan joins lobby firm MORE’s (D-Ark.) amendment passed by voice vote. It establishes a program for U.S. Customs and Border Protection and U.S. Immigration and Customs Enforcement to hire veterans.

Finally, an amendment from Sen. Dean HellerDean HellerSenate rejects ObamaCare repeal, replacement amendment OPINION | Healthcare vote a political death wish for GOP in 2018 Dem campaign arm slams Heller, Flake on healthcare votes MORE (R-Nev.) that would allow Nevada to participate in the Southern Border Security Commissions to make recommendation on how to best secure the border passed on a 89-9 vote.

Earlier Wednesday, the Senate voted 61-37 to table an amendment from Sen. Rand PaulRand PaulSenate rejects ObamaCare repeal, replacement amendment Overnight Healthcare: Senate votes to begin ObamaCare repeal debate | McCain returns to vote | GOP floats scaled-down healthcare bill Overnight Regulation: House votes to repeal forced arbitration rule | Dems look to ban controversial pesticide | House panel wants to hear from tech CEOs on net neutrality MORE (R-Ky.), essentially killing his border security amendment.