Most Republican senators voted against Dorsey's confirmation — Sen. Susan CollinsSusan Margaret CollinsTrump's plan to claw back spending hits wall in Congress Dem rep to launch discharge petition to force net neutrality vote in House Hillicon Valley: Senate votes to save net neutrality | Senate panel breaks with House, says Russia favored Trump in 2016 | Latest from Cambridge Analytica whistleblower | Lawmakers push back on helping Chinese tech giant MORE (Maine) voted for her.

Senate Judiciary Committee ranking member Chuck GrassleyCharles (Chuck) Ernest GrassleyThis week: House GOP regroups after farm bill failure Kennedy retirement rumors shift into overdrive How House Republicans scrambled the Russia probe MORE (R-Iowa) said he opposed Dorsey’s nomination because she has no criminal law experience and there are unanswered questions about campaign donations she has made.

“We want judges who will be restrained by precedent and laws Congress passes,” Grassley said. “I’m unconvinced she’ll be able to lay her policy preferences aside.”

The Senate is expected to consider several more of the president’s nominees before leaving for the August recess. But if Republicans continue to block Obama's cabinet nominees, some Democrats have pushed for the "nuclear option" — changing the rules on a simple-majority vote. It is unclear if it will come to that.

Earlier Tuesday, Senate Minority Leader Mitch McConnellAddison (Mitch) Mitchell McConnellTrump's plan to claw back spending hits wall in Congress GOP lawmakers want Trump to stop bashing Congress Parkland father calls out Trump, McConnell, Ryan after Santa Fe shooting MORE (R-Ky.) accused Democrats of “cooking up phony nomination fights.”

“Already in this Congress, the Senate has approved 27 of President Obama’s lifetime appointments. That compares to just 10 at a comparable point in President Bush’s second term,” McConnell said. “In other words, President Obama has just settled back into office, and already he’s secured nearly three-times more comparable judicial confirmations.”