Most Republican senators voted against Dorsey's confirmation — Sen. Susan CollinsSusan CollinsRussia probes in limbo after special prosecutor announcement GOP senator slams 'lack of leadership' coming from Trump GOP senators push Trump for DOE research funding MORE (Maine) voted for her.

Senate Judiciary Committee ranking member Chuck GrassleyChuck GrassleyGOP talks of narrowing ‘blue-slip’ rule for judges Grassley: Don't expect anti-Trump leaks to stop after special counsel appointed GOP senator wouldn’t be ‘surprised’ if Comey forced to cancel testimony MORE (R-Iowa) said he opposed Dorsey’s nomination because she has no criminal law experience and there are unanswered questions about campaign donations she has made.

“We want judges who will be restrained by precedent and laws Congress passes,” Grassley said. “I’m unconvinced she’ll be able to lay her policy preferences aside.”

The Senate is expected to consider several more of the president’s nominees before leaving for the August recess. But if Republicans continue to block Obama's cabinet nominees, some Democrats have pushed for the "nuclear option" — changing the rules on a simple-majority vote. It is unclear if it will come to that.

Earlier Tuesday, Senate Minority Leader Mitch McConnellMitch McConnellConservative groups press Senate on ObamaCare repeal Week ahead: Trump budget coming Tuesday | CBO to unveil health bill score | House hearing on border tax Week ahead: EPA braces for Trump budget MORE (R-Ky.) accused Democrats of “cooking up phony nomination fights.”

“Already in this Congress, the Senate has approved 27 of President Obama’s lifetime appointments. That compares to just 10 at a comparable point in President Bush’s second term,” McConnell said. “In other words, President Obama has just settled back into office, and already he’s secured nearly three-times more comparable judicial confirmations.”