The Senate on Thursday voted 54-46 to confirm Tom Perez as secretary of Labor.

It was a party-line vote, with no Republicans supporting President Obama's nominee.

Several GOP senators have charged that Perez had engaged in “ethically questionable” actions while heading the Civil Rights division of the Department of Justice.

Republicans agreed to hold an up-or-down vote on the nomination as part of a deal to avoid the "nuclear option" to end filibusters, but they made clear their strong disapproval of Perez on Thursday.

Senate Minority Leader Mitch McConnellAddison (Mitch) Mitchell McConnellMcConnell says he backs Mueller probe after classified briefing Overnight Finance: Trump signs Dodd-Frank rollback | Snubs key Dems at ceremony | Senate confirms banking regulator | Lawmakers lash out on Trump auto tariffs Senate Dems’ campaign chief ‘welcomes’ midterm support from Clintons MORE (R-Ky.) accused the new Labor secretary of making "misleading" statements to Congress and an inspector general during his service in the administration.

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“Tom Perez is more than just some left-wing ideologue, he’s a left-wing ideologue who appears perfectly willing to bend the rules to achieve his ends,” McConnell said. “This is reflective not of some passionate left-winger who views himself as patiently advancing policies within the bounds of a democratic system but as a crusading ideologue whose convictions lead him to believe that the law simply doesn’t apply to him.”

Sen. Marco RubioMarco Antonio RubioHillicon Valley: Experts worry North Korea will retaliate with hacks over summit | FBI works to disrupt Russian botnet | Trump officials look to quell anger over ZTE | Obama makes case for tighter regs on tech Putting pressure on Trump, House passes bill barring government from doing business with ZTE The Hill's Morning Report — Sponsored by PhRMA — Tensions mount for House Republicans MORE (R-Fla.) urged his Republican colleagues to vote no because he said Perez had failed to answer lawmakers’ questions during congressional hearings.

“How can we possibly — I don’t care what deal was cut — how can we move forward on someone who hasn’t provided information asked for by a congressional committee?”

Democrats defended Perez and hailed the end of the months-long Senate battle over his confirmation.

“Filling the position of Labor secretary couldn’t be more important,” Sen. Patty MurrayPatricia (Patty) Lynn MurrayOvernight Health Care — Sponsored by PCMA — Trump official won't OK lifetime limits on Medicaid Dems warn against changes to federal family planning program Overnight Health Care: Drug company under scrutiny for Michael Cohen payments | New Ebola outbreak | FDA addresses EpiPen shortage MORE (D-Wash.) said ahead of the vote. “Our country and our economy are stronger when the Department of Labor has a talented and qualified leader at the reins. … The president has nominated someone who will bring passion, integrity and a lifetime of experience to this important position.”

Senate Health, Education, Labor and Pensions Committee Chairman Tom HarkinThomas (Tom) Richard HarkinDem Senator open to bid from the left in 2020 Senate GOP rejects Trump’s call to go big on gun legislation Trump should require federal contractors to follow the law MORE (D-Iowa) said Perez has the "strongest reputation of professional integrity" and has acted "ethically."