Some Republicans are threatening to shutdown the government unless ObamaCare is delayed or repealed. Isakson said that was a “bad idea.”

“Government shutdowns are a bad idea,” Isakson said on the Senate floor Thursday.

Sen. Ted CruzRafael (Ted) Edward CruzOvernight Health Care: Trump eases rules on insurance outside ObamaCare | HHS office on religious rights gets 300 complaints in a month | GOP chair eyes opioid bill vote by Memorial Day HHS official put on leave amid probe into social media posts Trump, Pence to address CPAC this week MORE’s (R-Texas) 21-hour long speech aimed at convincing his colleagues to block a continued spending resolution prompted Isakson’s comment.

Last week, the House passed H.J.Res. 59, which would fund the government through mid-December, but defunds ObamaCare. The Senate has taken up that measure, but Cruz complained that Senate Majority Leader Harry ReidHarry Mason ReidWATCH: There is no Trump-Russia collusion and the media should stop pushing this The demise of debate in Congress ‘North by Northwest,’ the Carter Page remake MORE (D-Nev.) filed an amendment restoring funds for ObamaCare.

“While I respect and appreciate everyone’s views in the Senate, I think it is irresponsible for us to vote to shut down the government,” Isakson said.

Unless an agreement is reached to hold the vote sooner, the Senate will vote to end debate on the spending measure Friday morning. If Reid’s amendment is added to the bill later in the week, the resolution will be sent back to the House. Tea Party House members are threatening to add more restrictions to ObamaCare — something President Obama has said would cause him to veto the legislation.

Isakson said he would vote for cloture on the resolution, but vote against Reid's amendment funding ObamaCare.