Some Republicans are threatening to shutdown the government unless ObamaCare is delayed or repealed. Isakson said that was a “bad idea.”

“Government shutdowns are a bad idea,” Isakson said on the Senate floor Thursday.

Sen. Ted CruzRafael (Ted) Edward CruzSenate Dems hold floor talk-a-thon against latest ObamaCare repeal bill Overnight Finance: CBO to release limited analysis of ObamaCare repeal bill | DOJ investigates Equifax stock sales | House weighs tougher rules for banks dealing with North Korea GOP state lawmakers meet to plan possible constitutional convention MORE’s (R-Texas) 21-hour long speech aimed at convincing his colleagues to block a continued spending resolution prompted Isakson’s comment.

Last week, the House passed H.J.Res. 59, which would fund the government through mid-December, but defunds ObamaCare. The Senate has taken up that measure, but Cruz complained that Senate Majority Leader Harry ReidHarry ReidThe Memo: Trump pulls off a stone-cold stunner The Memo: Ending DACA a risky move for Trump Manchin pressed from both sides in reelection fight MORE (D-Nev.) filed an amendment restoring funds for ObamaCare.

“While I respect and appreciate everyone’s views in the Senate, I think it is irresponsible for us to vote to shut down the government,” Isakson said.

Unless an agreement is reached to hold the vote sooner, the Senate will vote to end debate on the spending measure Friday morning. If Reid’s amendment is added to the bill later in the week, the resolution will be sent back to the House. Tea Party House members are threatening to add more restrictions to ObamaCare — something President Obama has said would cause him to veto the legislation.

Isakson said he would vote for cloture on the resolution, but vote against Reid's amendment funding ObamaCare.