Mikulski’s comments came just minutes after the Senate voted to again remove House language related to ObamaCare from a continued spending resolution.

Lawmakers need to reach an agreement by midnight on legislation to fund the government otherwise it would shutdown.

The House continuing resolution (CR) would fund the government through Dec. 15. It would delay the individual insurance coverage mandate and the insurance exchanges, which are set to launch Tuesday, and eliminate a 2.3 percent tax on medical devices.

But Democrats have said they want a “clean” CR to prevent a shutdown.

“We have just tabled the radical bill that the House sent over to us,” Mikulski said. “It was deliberately designed to be politically provocative. … Continuing Resolutions were always about disputes over money not about political, ideological viewpoints on past legislation.”

Mikulski listed several federal agencies that would have to close their doors in event of a government shutdown, including the National Institutes of Health and the National Weather Service, which are both located in her state.

"I say to my colleagues on the other side of the dome, please let's pass a clean CR that funds the government through Nov. 15," Mikulski said. "Let's find a middle ground."