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Cruz led House Republicans in shutting down the government for more than two weeks in order to reform and delay parts of ObamaCare. Some Senate Republicans criticized that move because it lasted long enough to risk economic default, which the administration says will occur Thursday.

Ayotte’s remarks came moments after Senate leaders Harry ReidHarry ReidCharles Koch thanks Harry Reid for helping his book sales Warren cautions Dems against infighting Dems see surge of new candidates MORE (D-Nev.) and Mitch McConnellMitch McConnellGOP senator: Don't expect Trump to 'have your back' on healthcare vote Senate Dems step up protests ahead of ObamaCare repeal vote Johnson becomes fourth GOP senator unwilling to proceed on healthcare bill MORE (R-Ky.) announced a bipartisan fiscal deal.

The Senate bill would end the shutdown, fund the government through Jan. 15 and raise the debt ceiling until Feb. 7. It also calls for a budget conference between the House and Senate that would have to report back by Dec. 15 and requires stricter income verification for recipients of ObamaCare subsidies. Both the House and Senate are expected to vote on the bill Wednesday evening.

Ayotte said she hopes Republicans will focus their future negotiations on reducing the debt, rather than repealing ObamaCare — although she does oppose the law.