Republican Sens. Shelley Moore CapitoShelley Wellons Moore CapitoLots of love: Charity tennis match features lawmakers teaming up across the aisle Senate takes symbolic shot at Trump tariffs America must act to ensure qualified water workforce MORE (W.Va.) and Susan CollinsSusan Margaret CollinsOvernight Health Care: Novartis pulls back on drug price hikes | House Dems launch Medicare for All caucus | Trump officials pushing ahead on Medicaid work requirements Senate panel to vote next week on banning 'gag clauses' in pharmacy contracts GOP senator: Trump's changing stances on Russian threat are 'dizzying' MORE (Maine) said on Tuesday that they will not support moving forward with the plan to repeal ObamaCare with a delayed replacement.

"My position on this issue is driven by its impact on West Virginians. With that in mind, I cannot vote to repeal ObamaCare without a replacement plan that addresses my concerns and the needs of West Virginians," Capito said in a statement.

Collins said that she is still a "no" on proceeding to the House-passed bill, which would be used as a vehicle for any Senate action.

“We can’t just hope that we will pass a replacement within the next two years. Repealing without a replacement would create great uncertainty for individuals who rely on the [Affordable Care Act] and cause further turmoil in the insurance markets," she said.

She added that she's recommended Sen. Lamar AlexanderAndrew (Lamar) Lamar AlexanderBipartisan bill would bring needed funds to deteriorating National Park Service infrastructure Sens introduce bipartisan bill matching Zinke proposed maintenance backlog fix Supreme Court vacancy throws Senate battle into chaos MORE (R-Tenn.), the chairman of the Senate's Heath, Education, Labor and Pensions Committee, "begin to hold hearings to examine ways to fix the many flaws in the ACA so that it will work better for all Americans.”

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The announcements effectively put the healthcare push in limbo. With a 52-seat majority, Senate Majority Leader Mitch McConnellAddison (Mitch) Mitchell McConnellSenate GOP breaks record on confirming Trump picks for key court Senate Democrats block resolution supporting ICE The Hill's Morning Report — Trump’s walk-back fails to stem outrage on Putin meeting MORE (R-Ky.) can only afford to lose two senators and still let Vice President Pence break a tie.

Sen. John McCainJohn Sidney McCainEx-Montenegro leader fires back at Trump: ‘Strangest president' in history McCain: Trump plays into 'Putin's hands' by attacking Montenegro, questioning NATO obligations Joe Lieberman urges voters to back Crowley over Ocasio-Cortez in general MORE (R-Ariz.) is in Arizona this week recovering from surgery, so McConnell will not have 50 votes until he returns.

If another GOP senator comes out against moving to the bill, McCain's presence will not save it.

Sen. Rob PortmanRobert (Rob) Jones PortmanBipartisan bill would bring needed funds to deteriorating National Park Service infrastructure The Memo: Trump allies hope he can turn the page from Russian fiasco Trump seeks to quell Russia furor MORE (R-Ohio) said early Tuesday he would need to review the bill, but told reporters that a repeal-only bill "will add to more uncertainty." 

Other senators who balked at the last version of the healthcare bill say they will support moving to the repeal-only bill.

Sen. Jerry MoranGerald (Jerry) MoranLobbying world This week: GOP mulls vote on ‘abolish ICE’ legislation Hillicon Valley: Lawmakers eye ban on Chinese surveillance cameras | DOJ walks back link between fraud case, OPM breach | GOP senators question Google on Gmail data | FCC under pressure to delay Sinclair merger review MORE (R-Kan.), who announced his opposition to the repeal-and-replace bill Monday night, said he would support taking up the House-passed legislation.

"I support the President’s efforts to repeal ObamaCare, and I will vote in favor of the motion to proceed. This should be followed by an open legislative process to craft healthcare policy that will provide greater personal choice, protections for pre-existing conditions, increased access and lower overall costs for Kansans," Moran said.

McConnell is doubling down on the new strategy after he announced on Monday night that the Senate would try to separate ObamaCare repeal and replacement amid growing pressure from President Trump and conservatives.

"I believe we must continue to push forward now. I regret that the effort to repeal and immediately replace the failures of ObamaCare will not be successful. That doesn't mean we should give up," he said from the Senate floor on Tuesday.

The 2015 ObamaCare repeal bill passed the Senate 52-47, with Collins and then-Sen. Mark KirkMark Steven KirkThis week: Trump heads to Capitol Hill Trump attending Senate GOP lunch Tuesday High stakes as Trump heads to Hill MORE (Ill.) the only Republicans to oppose it.

Capito, who previously voted for the 2015 repeal bill, added on Tuesday that she has concerns about what would happen to her state's Medicaid expansion and combating opioid addiction.

"All of the Senate healthcare discussion drafts have failed to address these concerns adequately," the West Virginia senator said.

The 2015 measure guts ObamaCare by repealing authority for the federal government to run healthcare exchanges and scrapping subsidies to help people afford plans bought through those exchanges. It zeros out the penalties on individuals who do not buy insurance and employers who do not offer health insurance.

Crucially for moderate senators, the bill would end ObamaCare's Medicaid expansion in two years.

The Senate is expected to be in session until August 11, when members will leave town until early September.

Conservatives and Trump are pressuring GOP senators to back the legislation, noting most of them supported the measure in 2015 when they knew then-President Obama would veto it.

"I don’t see how any Republican senator who voted just 18 months ago for this very piece of legislation could now flip-flop 18 months on with ObamaCare still inflicting so much harm on Americans, and the fact that we campaigned on this for four straight elections," Sen. Tom CottonThomas (Tom) Bryant CottonBipartisan group introduces retirement savings legislation in Senate Overnight Defense: Fallout from tense NATO summit | Senators push to block ZTE deal in defense bill | Blackwater founder makes new pitch for mercenaries to run Afghan war Hillicon Valley: DOJ appeals AT&T-Time Warner ruling | FBI agent testifies in heated hearing | Uproar after FCC changes rules on consumer complaints | Broadcom makes bid for another US company | Facebook under fire over conspiracy sites MORE (R-Ark.) told conservative radio host Hugh Hewitt on Tuesday.

But several GOP senators voiced concerns earlier this year about repealing ObamaCare without a replacement plan hashed out.

Portman, Collins, and GOP Sens. Bob CorkerRobert (Bob) Phillips CorkerTrump’s damage control falters Trump says Russia doesn’t pose threat, contradicting intelligence director Fed Chair Powell's charm offensive touts a booming economy MORE (Tenn.), Bill Cassidy (La.) and Lisa MurkowskiLisa Ann MurkowskiThis week: GOP mulls vote on ‘abolish ICE’ legislation Dem infighting erupts over Supreme Court pick McConnell: Senate to confirm Kavanaugh by Oct. 1 MORE (Alaska) urged leadership for more time to come up with a repeal plan earlier this year.

GOP leadership initially wanted to pass a repeal-only bill but backtracked over a lack of support. GOP Sen. John ThuneJohn Randolph ThuneSenators share their fascination with sharks at hearing Helsinki summit becomes new flashpoint for GOP anger Senate weighs new Russia response amid Trump backlash MORE (R-S.D.) acknowledged on Tuesday that they could still fall short.

"We’ll now have to go through the exercise of sort of re-whipping this, because we are using live ammunition. You know, when we had this 18 months ago in 2015, we had a Democrat president that everybody knew would veto the bill," he told Hugh Hewitt.

Repealing portions of ObamaCare without enacting a replacement could leave 18 million people without health insurance the following year, according to a report released Congressional Budget Office (CBO) in January.

After the elimination of ObamaCare's Medicaid expansion and insurance subsidies, 27 million people would lose insurance, and then 32 million by 2026, the CBO found.

- This story was updated at 11:47 a.m.