Republican Sens. Shelley Moore CapitoShelley Wellons Moore CapitoSenate women: Rules on harassment must change Congress, here's a CO2-smart tax fix to protect, create jobs Women, Dems leading sexual harassment discussion in Congress: analysis MORE (W.Va.) and Susan CollinsSusan Margaret CollinsOvernight Health Care: 3.6M signed up for ObamaCare in first month | Ryan pledges 'entitlement reform' next year | Dems push for more money to fight opioids Study: ObamaCare bills backed by Collins would lower premiums Right scrambles GOP budget strategy MORE (Maine) said on Tuesday that they will not support moving forward with the plan to repeal ObamaCare with a delayed replacement.

"My position on this issue is driven by its impact on West Virginians. With that in mind, I cannot vote to repeal ObamaCare without a replacement plan that addresses my concerns and the needs of West Virginians," Capito said in a statement.

Collins said that she is still a "no" on proceeding to the House-passed bill, which would be used as a vehicle for any Senate action.

“We can’t just hope that we will pass a replacement within the next two years. Repealing without a replacement would create great uncertainty for individuals who rely on the [Affordable Care Act] and cause further turmoil in the insurance markets," she said.

She added that she's recommended Sen. Lamar AlexanderAndrew (Lamar) Lamar AlexanderOvernight Finance: Trump says shutdown 'could happen' | Ryan, conservatives inch closer to spending deal | Senate approves motion to go to tax conference | Ryan promises 'entitlement reform' in 2018 Senate approves motion to go to tax conference House conservatives, Ryan inch closer toward spending deal MORE (R-Tenn.), the chairman of the Senate's Heath, Education, Labor and Pensions Committee, "begin to hold hearings to examine ways to fix the many flaws in the ACA so that it will work better for all Americans.”

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The announcements effectively put the healthcare push in limbo. With a 52-seat majority, Senate Majority Leader Mitch McConnellAddison (Mitch) Mitchell McConnellGOP strategist donates to Alabama Democrat McConnell names Senate GOP tax conferees Brent Budowsky: A plea to Alabama voters MORE (R-Ky.) can only afford to lose two senators and still let Vice President Pence break a tie.

Sen. John McCainJohn Sidney McCainGOP strategist donates to Alabama Democrat Meghan McCain knocks Bannon: 'Who the hell are you' to criticize Romney? Dems demand Tillerson end State hiring freeze, consult with Congress MORE (R-Ariz.) is in Arizona this week recovering from surgery, so McConnell will not have 50 votes until he returns.

If another GOP senator comes out against moving to the bill, McCain's presence will not save it.

Sen. Rob PortmanRobert (Rob) Jones PortmanMcConnell names Senate GOP tax conferees Overnight Finance: House approves motion to go to tax conference — with drama | GOP leaders to consider Dec. 30 spending bill | Justices skeptical of ban on sports betting | Mulvaney won't fire official who sued him How four GOP senators guided a tax-bill victory behind the scenes MORE (R-Ohio) said early Tuesday he would need to review the bill, but told reporters that a repeal-only bill "will add to more uncertainty." 

Other senators who balked at the last version of the healthcare bill say they will support moving to the repeal-only bill.

Sen. Jerry MoranGerald (Jerry) MoranMcConnell works to salvage tax bill GOP in furious push for tax-reform votes Overnight Tech: Lawmakers want answers on Uber breach | Justices divided in patent case | Tech makes plea for net neutrality on Cyber Monday MORE (R-Kan.), who announced his opposition to the repeal-and-replace bill Monday night, said he would support taking up the House-passed legislation.

"I support the President’s efforts to repeal ObamaCare, and I will vote in favor of the motion to proceed. This should be followed by an open legislative process to craft healthcare policy that will provide greater personal choice, protections for pre-existing conditions, increased access and lower overall costs for Kansans," Moran said.

McConnell is doubling down on the new strategy after he announced on Monday night that the Senate would try to separate ObamaCare repeal and replacement amid growing pressure from President Trump and conservatives.

"I believe we must continue to push forward now. I regret that the effort to repeal and immediately replace the failures of ObamaCare will not be successful. That doesn't mean we should give up," he said from the Senate floor on Tuesday.

The 2015 ObamaCare repeal bill passed the Senate 52-47, with Collins and then-Sen. Mark KirkMark KirkHigh stakes as Trump heads to Hill Five things to watch for at Trump-Senate GOP meeting Giffords, Scalise highlight party differences on guns MORE (Ill.) the only Republicans to oppose it.

Capito, who previously voted for the 2015 repeal bill, added on Tuesday that she has concerns about what would happen to her state's Medicaid expansion and combating opioid addiction.

"All of the Senate healthcare discussion drafts have failed to address these concerns adequately," the West Virginia senator said.

The 2015 measure guts ObamaCare by repealing authority for the federal government to run healthcare exchanges and scrapping subsidies to help people afford plans bought through those exchanges. It zeros out the penalties on individuals who do not buy insurance and employers who do not offer health insurance.

Crucially for moderate senators, the bill would end ObamaCare's Medicaid expansion in two years.

The Senate is expected to be in session until August 11, when members will leave town until early September.

Conservatives and Trump are pressuring GOP senators to back the legislation, noting most of them supported the measure in 2015 when they knew then-President Obama would veto it.

"I don’t see how any Republican senator who voted just 18 months ago for this very piece of legislation could now flip-flop 18 months on with ObamaCare still inflicting so much harm on Americans, and the fact that we campaigned on this for four straight elections," Sen. Tom CottonTom CottonGOP and Dems bitterly divided by immigration Grassley offers DACA fix tied to tough enforcement measures Five things senators should ask Tom Cotton if he’s nominated to lead the CIA MORE (R-Ark.) told conservative radio host Hugh Hewitt on Tuesday.

But several GOP senators voiced concerns earlier this year about repealing ObamaCare without a replacement plan hashed out.

Portman, Collins, and GOP Sens. Bob CorkerRobert (Bob) Phillips CorkerFormer Dem Tenn. gov to launch Senate bid: report McConnell 'almost certain' GOP will pass tax reform Former New Mexico gov: Trump's foreign policy is getting 'criticized by everybody' MORE (Tenn.), Bill Cassidy (La.) and Lisa MurkowskiLisa Ann MurkowskiMcConnell names Senate GOP tax conferees Week ahead: Trump expected to shrink two national monuments GOP on verge of opening Arctic refuge to drilling MORE (Alaska) urged leadership for more time to come up with a repeal plan earlier this year.

GOP leadership initially wanted to pass a repeal-only bill but backtracked over a lack of support. GOP Sen. John ThuneJohn Randolph ThuneMcConnell names Senate GOP tax conferees Overnight Health Care: 3.6M signed up for ObamaCare in first month | Ryan pledges 'entitlement reform' next year | Dems push for more money to fight opioids Dems push for more money for opioid fight MORE (R-S.D.) acknowledged on Tuesday that they could still fall short.

"We’ll now have to go through the exercise of sort of re-whipping this, because we are using live ammunition. You know, when we had this 18 months ago in 2015, we had a Democrat president that everybody knew would veto the bill," he told Hugh Hewitt.

Repealing portions of ObamaCare without enacting a replacement could leave 18 million people without health insurance the following year, according to a report released Congressional Budget Office (CBO) in January.

After the elimination of ObamaCare's Medicaid expansion and insurance subsidies, 27 million people would lose insurance, and then 32 million by 2026, the CBO found.

- This story was updated at 11:47 a.m.