The Senate is expected to vote on the legislation Wednesday.
The Nevada Democrat said that it "turns my stomach" to hear discussions of a peace deal in Syria that includes Syrian President Bashar al-Assad.
Senators are expected to vote on a long-stalled bill to curb human trafficking.
Mazie Hirono would increase the max Pell Grant and expand aid programs to "Dreamers."
The bill will be placed on the Senate's calendar without going through the committee process.
The Senate Majority leader plans a series of votes for Wednesday.
The Senate could take a procedural vote Thursday on the attorney general nominee.
Lawmakers are "not close to a consensus" on action against ISIS.
The Arizona Republican said that if Republicans don't address immigration "we do not win the 2016 election."
Sen. Ben Cardin said Republicans have "a lot of interest" in putting forward amendments.