He said he's against the deal because it raises discretionary spending above sequestration levels.
The Senate leader is pushing Republicans to yield time on President Obama's nominees.
The House measure would provide doctors with a 0.5 percent payment update through March.
Sen. John Rockefeller (D-W.Va.) urged his colleagues Wednesday to allow diplomatic efforts with Iran to go forward without the Senate passing any additional sanctions.
“If there is any chance at all that new sanctions right now might disrupt the agreement … why on earth would we risk that?” Rockefeller said on the Senate floor.
The House approved legislation on Wednesday that would allow the Department of Veterans Affairs to dig up and remove deceased veterans from military cemeteries if they are found to have committed a capital crime.
A group of Democratic senators asked for unanimous consent Wednesday to vote on a bill aimed at delaying flood insurance rate increases.
Sen. Bill Menendez (D-N.J.), the lead sponsor of S. 1610, asked for two hours of debate and a 60-vote threshold for final passage, but Sen. Pat Roberts (R-Kan.) objected.
The House on Wednesday approved legislation that would boost funding for research into pediatric diseases, a bill that was made a priority in recent weeks by House Majority Leader Eric Cantor (R-Va.).
Senate Minority Leader Mitch McConnell (R-Ky.) accused Democrats of manufacturing a fight on President Obama’s nominees in order to distract the public from the failures of ObamaCare.
“The left believes the president’s agenda runs straight through the D.C. Circuit Court, that’s why they pressured Senate Democrats to break the rules to change rules — to pack the D.C. Circuit Court,” McConnell said Wednesday. “None of it should distract us from what ObamaCare is doing to our healthcare system.”
The vote on the Defense bill would occur under a suspension process.
Reid said Democrats will push for an extension when the Senate returns in January.