The vote comes as the administration and lawmakers grapple with the Syrian humanitarian crisis.
It establishes a program to help train local law enforcement.
But the Arkansas senator is keeping his block on one ambassador nomination.
He said that lawmakers must be "mindful" of the consequences of their actions.
He says the EPA's current rules probably won't "survive much longer anyway."
Ryan said Americans deserve "solutions that address the challenges they face."
Sanders is expected to resume his Senate work on Tuesday.
Lawmakers return to Washington after a week-long recess.
Lydia Wheeler 11/30/15 06:00 AM EST
The current rules would create a de-facto ban on products presently available, it says.
The Senate may also take up an ObamaCare repeal bill.