The 287-page rule orders that industry players begin collecting their data on Aug. 1 and report it to CMS by March 31, 2014.
Payment categories will include consulting fees, honoraria, gifts, food, entertainment, travel and charitable contributions, among others. Industry players are required to report their payments if they are covered by any federal health program.
The rule also stated that it preempts similar state laws, creating the possibility of "cost-savings, since a single reporting system for reporting this information is less burdensome than multiple programs."
Sen. Chuck Grassley (R-Iowa), an author of the original bill, said in a statement that the new rule will "bring about accountability, and accountability will strengthen the credibility of medical research, the marketing of ideas, and, ultimately, the practice of medicine."
"I will stay vigilant about how this law is implemented, especially after the delays seen already," Grassley added.
The regulations outline a 45-day "review and correction" period for doctors to ensure the accuracy of any disclosures to CMS.
The American Medical Association (AMA) withheld judgment Friday, saying it would "carefully review" the rule.
"Our feedback during this rulemaking process was aimed at ensuring the new registry will provide a meaningful picture of physician-industry interactions and give physicians an easy way to correct any inaccuracies," said AMA President Jeremy Lazarus in a statement.
"As the rule is implemented, we will work to make sure physicians have up-to-date information about the new reporting process.”