Reid said he hopes the GOP will "work with us" to replace Sebelius quickly.
Obama has selected his OMB director to replace Sebelius.
"Unfortunately, a page is missing," she announced in the middle of her resignation speech.
Republicans are hitting the healthcare law, not the departing HHS secretary.
PhRMA elected three new senior members during the trade group’s annual meeting on Friday.
She will be replaced by Sylvia Burwell, who is now President Obama's budget director.
Health and Human Services Secretary Kathleen Sebelius on Thursday told lawmakers that enrollments in ObamaCare's exchanges have reached 7.5 million.
The Senate Health Committee is forming a working group to tackle the rising rates of prescription drug abuse, as the fight wages on over a controversial painkiller the Food and Drug Administration approved last year.
Sebelius made the comment before the Senate Finance Committee.
The poll found 54 percent call the law "very important" in determining their vote.