The FCC calls the law the most significant accessibility legislation since the Americans with Disabilities Act.
Only 41 percent of Americans with disabilities have high-speed Internet access at home, compared to 69 percent nationally, according to FCC data.
Commissioner Robert McDowell said the rules would help the 54 million Americans with disabilities gain access to online communication.
"At the same time, we have provided the certainty necessary for the innovators investing risk capital to continue to satisfy consumer demand with new products and services," he added.
Commissioner Michael Copps dissented from the order in part. He believes that the commission should have included automatic software updates under the rules' requirements.