Second lady Jill Biden will lead the presidential delegation to the 2011 Special Olympics World Summer Games in Athens, Greece.
She leaves Friday for the event, which serve more than 3.7 million people with intellectual disabilities.
Among the events she's participating in, according to a White House advisory: the lighting of the Flame of Hope on Friday; the Opening Ceremonies on Saturday; and the Special Olympics Aquatic Competition on Sunday.
Biden and the U.S. delegation will also attend a dedication ceremony for the naming of the Eunice Kennedy Shriver Square on Sunday. Shriver, who died 2009, was one of the founders of the Special Olympics.
While in Greece, Biden will also meet with staff and families at the U.S. Embassy in Athens. She'll also join Secretary of the Navy Ray Mabus for a visit to the USS Ramage.
This isn't her first time representing the U.S. at a world sporting event. In June 2010, she and husband Vice President Joe Biden represented the U.S. at the opening ceremony of the World Cup Games in South Africa.