The segment was pre-taped at Biden’s hotel in Iowa on Thursday morning. 

Biden isn't the first political player to give the "Late Show" nightly gag a go.

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In September, first lady Michelle ObamaMichelle ObamaMelania Trump to lead US delegation to Invictus Games Michelle Obama opens up about racism she faced as first lady Video surfaces of Michelle Obama at Beyonce’s birthday party MORE made a cameo on Letterman's show, reading, "The Top 10 reasons to watch the Democratic National Convention."

News of Biden’s appearance comes a day after a poll finds TV comedians love telling jokes about President Obama's and Biden’s political opponent. 

The study, released Wednesday by George Mason University’s Center for Media and Public Affairs, found that since the political parties' nominating conventions, late-night TV talk-show comedians have told more jokes about GOP presidential candidate Mitt Romney than almost all Democrats combined. While Obama came in a distant second place on the Top 10 list of targets of late-night political humor, Biden took the No. 8 slot, right behind actor Clint Eastwood.