Some of Hollywood’s most high-profile stars took to their feet at the Oscars when Vice President Biden made an appearance at the 88th annual awards ceremony.

“I’m the least-qualified man here tonight,” Biden quipped during the standing ovation. Director Steven Spielberg, “An Officer and a Gentleman” star Louis Gossett Jr. and actor Benicio del Toro were just a few of the famous faces seen in the audience that rose to applaud Biden.

The vice president was on hand for the Sunday telecast in Los Angeles to introduce a performance of Lady Gaga’s Oscar-nominated song, “Til it Happens to You.”

The song about campus sexual assault, co-written by Diane Warren, was penned for the documentary “The Hunting Ground.”

“Despite significant progress over the last few years,” Biden told the crowd, “too many women and men on and off college campuses are still victims of sexual abuse.”

Biden encouraged viewers to “take the pledge” and support the Obama administration’s “It’s On Us” campaign, which aims to promote awareness and prevention of sexual assault on campuses.

“We must and we can change the culture so that no abused woman or man — like the survivors you will see tonight — ever feel they have to ask themselves: ‘What did I do?’” Biden said.

Calling her his “friend” and a “courageous lady herself,” Biden introduced Lady Gaga.

The “Born This Way” singer offered a stirring rendition of the ballad, which featured a chorus of people baring different messages written on their arms, including the words “unbreakable” and “survivor.”