Cooper, People magazine’s 2011 “Sexiest Man Alive,” sat down with Biden at the White House earlier this year.

He also spoke at a January press conference on mental health at the Center for American Progress in downtown Washington with former Rep. Patrick Kennedy (D-R.I.) and Sen. Debbie StabenowDeborah (Debbie) Ann StabenowSenators push HHS to negotiate lower prices on opioid overdose reversal drug Senators press administration on mental health parity Progressive groups launch M midterm initiative in three battleground states MORE (D-Mich.).

UPDATE (2:30 p.m.): Cooper told a crowd at the conference Monday afternoon, "I think that all of us are touched in a real meaningful way with this illness. And I think it is up to all of us to help. I want to help, I want to do something about it. I want to be part of the solution," before introducing Biden.

The vice president quipped, "I'm Joe BidenJoseph (Joe) Robinette BidenThe Hill's 12:30 Report Biden to decide on White House run at end of year Stormy Daniels’s 'View' is incorrect MORE, and I'm a friend of Bradley Cooper."

During his closing remarks, Biden told a story about staying at the same hotel as the "Hangover" star during a recent trip to Brazil. Joking that the entertainer had "caused me a great deal of pain recently," Biden said he had to disappoint his 12-year-old granddaughter by meeting with the president of Brazil rather than summoning Cooper to his suite.

"My standing with my granddaughter has plummeted," Biden cracked.

Justin Sink contributed.