There was speculation in December of last year that Affleck would run for Senate in Massachusetts, to replace Secretary of State John Kerry. Affleck, a Boston native, and Kerry are close. The actor campaigned for Kerry's presidential campaign in 2004.
Affleck has remained politically active through his Eastern Congo Initiative and he's testified on Capitol Hill about ending the war in the Congo. He also held a fundraiser for Massachusetts Democrat Elizabeth Warren's 2012 Senate campaign.
Garner said she would support her husband if he makes the political leap.
"I'm along for the ride," she told the magazine.