There was speculation in December of last year that Affleck would run for Senate in Massachusetts, to replace Secretary of State John KerryJohn KerrySenators who have felt McCain's wrath talk of their respect for him Dems see huge field emerging to take on Trump Budowsky: Dems need council of war MORE. Affleck, a Boston native, and Kerry are close. The actor campaigned for Kerry's presidential campaign in 2004.

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But Affleck opted not to run and has seen his Hollywood career flourish: His film "Argo" won the Academy Award for Best Picture earlier this year.

Affleck has remained politically active through his Eastern Congo Initiative and he's testified on Capitol Hill about ending the war in the Congo. He also held a fundraiser for Massachusetts Democrat Elizabeth WarrenElizabeth WarrenDemocrats roll out 'Better Deal,' new economic agenda Jimmy Carter predicts US will eventually have single-payer healthcare system Dems to unveil ‘better deal’ messaging campaign Monday MORE's 2012 Senate campaign.

Garner said she would support her husband if he makes the political leap.

"I'm along for the ride," she told the magazine.