Fresh off her head-turning Golden Globes speech focused on the "Me Too" movement, Oprah Winfrey is going on-on-one with some of the biggest names in Hollywood about sexual misconduct.

In a segment for this week’s “CBS Sunday Morning,” the former talk show host will interview a slew of A-list actresses and top female film and TV execs — including Reese Witherspoon, Natalie Portman, America Ferrera, Tracee Ellis Ross and producer Shonda Rhimes, among others — about sexual harassment in the workplace.

“There’s moments where you have to evaluate whether silence is going to be your only option,” Witherspoon, who revealed last year that she was sexually assaulted by a director when she was 16, says in a clip from the interview released Friday. “And at certain times that was our only option — but now is not that time.”

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“You know, we have public voices. We have resources,” Witherspoon tells Winfrey, a CBS special correspondent, as part of the panel discussion.

“But women who are workers in this country have nothing to gain in certain times by coming forward. But we, we want to help. Like, it gives me strength to hopefully help other women,” she adds.

“We have to maintain the momentum of this conversation because they can’t,” Lucasfilm President Kathleen Kennedy added.

Several of the women interviewed for “CBS Sunday Morning” were part of a wide group of female Hollywood pros who announced the creation of the “Time’s Up” initiative earlier this month following "Me Too's" success. The effort is aimed at combating systemic sexual harassment.

Winfrey’s interview with the famous faces comes a week after she delivered a stirring speech at the 75th annual Golden Globes in which she railed against sexual misconduct in Hollywood and beyond. The remarks from the 63-year-old OWN founder stoked talk of a potential White House run against President TrumpDonald John TrumpGOP lawmakers preparing to vote on bill allowing migrant children to be detained longer than 20 days: report Wasserman Schultz: Infants separated from their parents are in Florida immigrant shelters Ex-White House ethics chief: Sarah Sanders tweet violates ethics laws MORE in 2020.

Although she’s previously denied any interest in running for office, Winfrey has not yet addressed the political speculation since her speech.

Multiple polls released this week showed Winfrey beating Trump in a hypothetical matchup, but one that came out Friday found that a majority doesn't want her to enter the race.