Republican calls for Rep. Todd Akin (R-Mo.) to drop out of the Missouri Senate race grew Tuesday, with several senators issuing calls for his exit. Sen. Kelly AyotteKelly Ann AyotteDems plan to make gun control an issue in Nevada Stale, misguided, divisive: minimum wage can't win elections Trump voter fraud commission sets first meeting outside DC MORE (R-N.H.), a campaign surrogate for Mitt Romney, was the latest to publicly ask him to “step aside.” 

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Romney had called Akin’s comments "insulting, inexcusable and, frankly, wrong” on Monday but did not call for him to drop out of the race until later in the afternoon.

Ayotte tweeted that Akin’s “comments are totally offensive” and said she agrees with National Republican Senatorial Committee (NRCC) Chairman John CornynJohn CornynGun proposal picks up GOP support House bill set to reignite debate on warrantless surveillance Republicans jockey for position on immigration MORE’s (R-Texas) recommendation that Akin rethink his bid for the Missouri Senate seat. Cornyn has reportedly suggested that the NRSC might not help fund Akin if he remains in the race.

Akin has so far resisted calls to step down. But Ayotte was not the only Republican senator calling for him to drop out of the race on Tuesday. Sens. Richard BurrRichard Mauze BurrTrump: Why isn't Senate looking into 'Fake News Networks'? Overnight Cybersecurity: Equifax security employee left after breach | Lawmakers float bill to reform warrantless surveillance | Intel leaders keeping collusion probe open Special counsel looking into dossier as part of Russia probe: report MORE (S.C.), Lisa MurkowskiLisa Ann MurkowskiRepublicans jockey for position on immigration GOP senator knocks Trump: 'Not a fan of governing by tweet' How the effort to replace ObamaCare failed MORE (Alaska) and Orrin HatchOrrin Grant HatchGOP eyes limits on investor tax break Children’s health-care bill faces new obstacles Overnight Finance: White House requests B for disaster relief | Ex-Equifax chief grilled over stock sales | House panel approves B for border wall | Tax plan puts swing-state Republicans in tough spot MORE (Utah) also tweeted, and Sen. Kay Bailey Hutchison (R-Texas) posted on her Facebook page.


"I urge the congressman to reconsider whether his continued candidacy for the U.S. Senate is in the best interest of his constituents," Hutchison wrote.

Akin caused a firestorm Sunday when he told a local Missouri TV station that "legitimate rape" rarely causes pregnancy for victims because "the female body has ways to try to shut that whole thing down."

Democrats have sought to tie Akin’s comment to the Republican presidential ticket.

"Although these particular comments have led Gov. Romney and other Republicans to distance themselves, I think the underlying notion that we should be making decisions on behalf of women for their healthcare decisions — or qualifying forcible rape versus non-forcible rape — I think those are broader issues, and that is a significant difference in approach between me and the other party," President Obama said Monday.

—Updated at 4:46 p.m.