Senate Majority Leader Harry Reid (D-Nev.), spurred on by activists and TV talk show host Oprah Winfrey, is planning round two against his nemesis: Tom Coburn, aka “Senator No.”

Reid’s office has sent word to Senate Democrats that it would like to bring the so-called Coburn omnibus bill to the floor soon, setting up a rematch with the conservative Oklahoma Republican who has often brought the Senate to gridlock.

Now Winfrey has squared off against Coburn, who has blocked S. 1738, the Combating Child Exploitation Act.

Winfrey asked her viewers Monday to call and write the Senate to demand their support for the legislation, sponsored by Democratic vice presidential nominee Joe Biden (Del.).

Winfrey, herself a victim of sexual abuse, has asked viewers to sign and send a letter posted on her website calling for action on the bill.

Winfrey’s show is the top recipient of campaign advertisements after the leading news programs.

Coburn initially  blocked it because it would have authorized nearly a billion dollars over eight years to fund a law enforcement crackdown on child exploitation. Coburn has insisted that new government programs be offset with spending cuts, a budget-saving device Biden’s bill lacked.

Coburn now wants Biden’s revised proposal paired with Republican legislation that would give law enforcement greater access to the online records of suspected sexual predators.

He questioned Winfrey’s political objectivity.

“I’m concerned that Oprah’s program only highlighted one half of the solution – the half supported by the presidential ticket she has endorsed.  While I support the right of celebrities to use their platforms to advance partisan goals, Oprah’s viewers deserve to know all of the facts,” Coburn said in a statement.

Reid bundled the Biden bill with nearly 35 other bills that Coburn has used Senate rules to block into a package known as the Coburn omnibus.

Reid fell eight votes short of moving the package through the Senate in July. In a surprise, Reid’s aides have told fellow Democrats he will try again this week — a mere six weeks after Coburn successfully blocked it previously.

Coburn has threatened procedural tactics to block dozens of relatively non-controversial bills during the 110th Congress.

The strategy has proven effective because Democratic leaders are not willing to waste days of floor time filing motions to proceed and holding votes to cut off debate to pass bills that have little national name recognition but are nevertheless very important to smaller constituencies.

Reid decided to bundle these smaller bills into an omnibus package to marshal a broader coalition of support. That effort failed, however, in July, when Democrats, plagued by absences within their caucus, could not whip together enough votes to overcome Coburn’s opposition.

“Oprah’s viewers deserve to know that Senate leaders have twice objected to passage of the bill she supports.  Senate leaders have insisted … [the bill] only pass if it is included in a package of unrelated bills that addresses less vital concerns such as the interstate commerce of non-human primates,” Coburn said.