At the same time, Stein hit a note of caution on easing, warning that future rounds of easing could show diminished returns in the economy.
"We could in principle push this tool to the point that the hurdle for additional usage would become very high," he said.
Skeptics of "QE3," including many GOP lawmakers, contend that the massive expansion of the Fed's balance sheet that comes with these purchases encourages inflation down the line, when it comes time for the Fed to sell those assets back into the marketplace.
Stein sought to assuage those concerns, contending that the Fed is well aware of the risks and is confident in its ability to keep prices under control.
"If the [Fed] needs to act in the face of an emerging threat to price stability, there is little doubt in my mind that we can," he said. "As to whether we will, the Federal Reserve has repeatedly made clear its commitment to both sides of its mandate — to price stability as well as to maximum employment."
The remarks mark Stein's first public speech since he joined the Fed. The Harvard economics professor was confirmed by the Senate in May by a vote of 70-24, alongside Jerome Powell, a Treasury under secretary under President George W. Bush. He was confirmed by a vote of 74-21.
President Obama nominated the pair in December.