By Elise Viebeck - 05/01/13 04:17 PM EDT
SAMHSA reported that half of all ER visits tied to zolpidem in 2010 involved another drug.
The agency warned that anti-anxiety medications and narcotic pain relievers "dangerously enhance" the sedative effects of drugs like Ambien.
"Although short-term sleeping medications can help patients, it is exceedingly important that they be carefully used and monitored," said SAMHSA Administrator Pamela S. Hyde in a statement.
"Physicians and patients need to be aware of the potential adverse reactions associated with any medication, and work closely together to prevent or quickly address any problems that may arise."