John Kerry (D-Mass) and Orrin Hatch (R-Utah), along with 59 other Senators, are putting pressure on the European Commission to hurry up and complete its investigation of Oracle's proposed $7.4 billion purchase of Sun Microsystems.
The Justice Department cleared the merger in August, saying it does not think the deal will be anticompetitive.
Kerry said further delay of the deal, which was announced in April, could "threaten thousands of American jobs."
"I have become increasingly concerned about the growing body of evidence that foreign regulatory agencies are unfairly using their review processes to impede the business of American corporations," Hatch said.
The letter was also signed by Dianne Feinstein (D-Calif.), Kay Bailey Hutchison (R-Texas) and Chris Dodd (D-Conn.).
They wrote: "Unfortunately, Sun Microsystems' financial position has become more precarious and the Commission's inquiry has continued. Some have raised concerns over the company's ability to continue to employ its thousands of workers. Accordingly, we respectfully request the European Commission complete its investigation of this transaction as quickly as possible."