Our investment in the National Institutes of Health (NIH) over the past three decades has led to landmark accomplishments such as the mapping of the human genome and the development of life-saving drugs that target specific cancers or lower cholesterol. Deaths from heart disease and stroke are down 63 percent and 70 percent, respectively, since the 1970s, and HIV has been transformed from a rapid death sentence to a chronic, manageable disease. Thanks to NIH-funded research, millions of lives have been saved and improved, and hope for the future is provided to millions more.