Last month at the National Institutes of Health (NIH), Secretary of State Hillary Clinton announced an ambitious new goal of achieving an AIDS-free generation. Just a few years ago, this would have seemed unattainable. But today, thanks to advances in HIV prevention and treatment research, we have an unprecedented opportunity to turn the tide against HIV/AIDS across the globe and here in the U.S., where 1.1 million people are living with HIV. As we mark World AIDS Day, reaching this incredible goal is now possible, but only if we follow the scientific evidence and commit the necessary resources.