The attendees at a dinner hosted by South African Foreign Minister Maite Nkoana-Mashabane cheered as Clinton got her groove on in the country's largest city, reported The Associated Press.
At one point it seemed Clinton even began to get, low, low, low, low on the dance floor.
Earlier in her trip Clinton donned traditional garb and showed off her moves during a brief stop in Malawi.
While in South Africa Clinton pledged to preserve the United States' preferential trade deal with Africa and said if President Obama is reelected he will immediately begin working with Congress to renew the deal.
She also held meetings with government officials and business leaders in South Africa, and earlier visited with South African icon and former President Nelson Mandela in Qunu.