She praised the president's handling of women's issues in light recent controversies over contraception and Planned Parenthood, as well as his push for healthcare reform.
"There is an attack on women's healthcare and President Obama's policies are the only ones that are going to move that forward or move the agenda for women's rights. There's some much dismantling of what we've accomplished as women by the right side," Longoria said on MSNBC's "Andrea Mitchell Reports" on Monday.
The "Desperate Housewives" star also had some harsh words for Obama opponent Mitt Romney.
"Those people who don't think that Latinos will vote for a Republican need to take a look in Puerto Rico and see there that conservative principals and Latino voters go together," said Romney after the primary.
Longoria said that out of all of the Republican presidential contenders, Romney is "the one on the wrong side of every issue pertaining to Latinos," including education, the economy and healthcare access.
"He's calling the anti-immigration law from Arizona a model law for the rest of the country. He's campaigning with the author of it. That's polarizing to Latinos," she said.
The Hollywood star told MSNBC that she took on the role of co-chairwoman to speak out to Latino, as well as women, voters.
"Obama for me is the only one for that understands that the success and future of American is intricately tied to the success of the Hispanic community," Longoria said.
When pressed on criticism of the president's lack of progress on immigration reform, Longoria defended Obama policies and blamed gridlock in Congress for the failure of comprehensive legislation.
"He's done what he can do without having his hands tied by Congress," she added.