"I didn't say I was confident … I'm hopeful he will and I believe he will. He's an engineer, he's a quantitative guy. I think at some point you have to add up the columns here, and my belief is that by anyway you add them up, they don't add up," said Blunt on MSNBC's "Daily Rundown."
"It's not helpful. He's a person who I think is ultimately going to look at this and try to figure out the greater good," Blunt added.
Akin was lambasted by Democrats as well as his own party after he gave an interview earlier this month in which he suggested a woman would not become pregnant from a “legitimate rape.” Republicans, including congressional leadership and the GOP presidential ticket, have called for him to step aside, and National Republican Senatorial Committee and super-PAC funding has been pulled from his race.
Despite the opposition, Akin vowed to continue, saying last week that "we're going to be here through the November election and we're going to be here to win." Blunt and several former Missouri Republican senators have publicly urged him to step down as the nominee.
Akin had been locked in a a tight race with incumbent Sen. Claire McCaskill (D-Mo.), but since Akin's comments the race has widened in the sitting senator's favor.
Former Arkansas Gov. Mike Huckabee (R) stood up for Akin, sending an email to supporters calling the effort to push Akin out "disgraceful."
"From the spotlights of political offices and media perches, it may appear that the demand for Akin’s head is universal in the party. I assure you it is not. There is a vast, but mostly quiet army of people who have an innate sense of fairness and don’t like to see a fellow political pilgrim bullied," wrote Huckabee.
Blunt, who said he hasn't spoken directly with Huckabee, told MSNBC that the former governor might have more "sympathy" for Akin, given his own experiences in the national media spotlight.
"Gov. Huckabee also needs to look at the greater context. No matter what he think is fair or whether he thinks this should be put away, all you have to do is look at any newspaper in America for the last week and I'd be surprised if you can't find multiple stories about this, instead of jobs and the economy and more American energy and getting people where they have more confidence that the government is going to do the right thing," he said.