The show features former "Seinfeld" actress Julia Louis-Dreyfus as the fictional vice president of the United States and former Sen. Selina Meyer.
Louis-Dreyfus and co-star Anna Chlumsky are expected to hit the town for the Wednesday premiere at the United States Institute of Peace in downtown D.C.
The new comedy was created by Armando Iannucci, director of the British television series "The Thick of It" and the political comedy "In the Loop," which also featured Chlumsky.
The national television premiere of "Veep" airs on HBO April 22.
For more on the Washington, D.C. premiere, check out The Hill's Washington Scene events listings here.