"This issue goes far beyond oversight — I believe this is a bit of overkill on the part of this committee ... they're making this stuff up and everybody knows it," Clyburn said on MSNBC's "Daily Rundown."
Clyburn said he believes "very sincerely" that he already has the answers he needs regarding the investigation into the Bureau of Alcohol, Tobacco, Firearms and Explosives's (ATF) former "Fast and Furious" gun-tracking program.
"When you get the answers you have to always take into account that this attorney general cannot allow himself to be bullied by people who are trying to push him to make mistakes ... I know exactly how this game is played," Clyburn said.
The Oversight Committee voted along party lines last week to recommend a contempt citation for Holder's failure to respond to a subpoena, launching a vote of the full House. Issa accused President Obama in a letter Tuesday of either obstructing a congressional investigation or of involvement in the "Fast and Furious" operation in response to the president's assertion of executive privilege last week to withhold documents related to "Fast and Furious."
Clyburn praised Holder for his handling of the situation.
"So far, Attorney General Holder is doing exactly what he ought to do, and that is run his office the way he was sworn to run it, and not allow himself to be bullied into doing things that could violate the law and destroy the credibility of the judicial system," he said.
Clyburn argued that three of the four gun-walking incidents that are under inquiry took place during President Bush's administration.
"Why is not Mr. Issa not asking for all of these records?" he said.
MSNBC reported that as many as 35 Democrats could join the Republicans in voting to place Holder in contempt of Congress.
Clyburn also weighed in on the Supreme Court ruling of Obama's healthcare reform law, which will be announced Thursday — the same day the House is expected to hold the contempt vote.
He told MSNBC that regardless of the high court's decision on the healthcare law, reform will continue to take place for many more years to come. Healso noted it took a period of eight years to complete civil rights legislation.
"I think it's going to take the same thing with healthcare, irrespective of what the Supreme Court may do. We are going to be working on accessibility of healthcare and affordability of healthcare for a longtime out into the future," Clyburn said.