In an interview on ABC's This Week, Kennedy said her late husband would have been "pleased but not surprised" by the high court's 5-4 decision and Chief Justice John Roberts' tie-breaking vote.
"I think If Teddy were here he would tell us, now it's time to roll up our sleeves, get to work, fully implement the law, and move on with the business of our country," she said.
During the interview, Kennedy praised minority leader and former House Speaker Nancy Pelosi, calling her a "real heroine" in the healthcare battle.
"She fought valiantly for healthcare," she said. "She led the House of Representatives beautifully in fighting and fighting and championing healthcare for all Americans."