"This guy is not a professional," he said. "Professionals are taught not to profile."
The rapper also voiced frustration with Florida's controversial "stand your ground" law.
"If you ask yourself the question, Didn't Trayvon have a right to stand his ground?" he said. "He was being chased. He fought back. He may have won. That doesn't mean he was a criminal."
The "stand your ground" self-defense laws in Florida and two dozen other states allow individuals to defend themselves without requiring them to attempt to evade or retreat from a dangerous situation. Although Zimmerman did not specifically employ a "stand your ground" law defense to combat the murder charges, the trial has brought a renewed scrutiny to the statutes.
Last week, President Obama said the laws were also worth of further scrutiny.
"If we're sending a message as a society in our communities that someone who is armed potentially has the right to use those firearms even if there's a way for them to exit from a situation, is that really going to be contributing to the kind of peace and security and order that we'd like to see?" the president asked.