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Sen. Rand PaulRandal (Rand) Howard PaulRand Paul calls for probe of Democrats over Ukraine letter Sunday Show Preview: Trump's allies and administration defend decision on Syria Ana Navarro clashes with Rand Paul in fiery exchange: 'Don't mansplain!' MORE (R-Ky.) is breaking with other Republican presidential hopefuls and backing President Obama's decision to launch talks normalizing relations with Cuba.

Paul criticized the trade and travel embargo on Cuba as ineffective, separating himself from former Florida Gov. Jeb Bush and Sens. Marco RubioMarco Antonio RubioFurious Republicans prepare to rebuke Trump on Syria Five ways Trump's Syria decision spells trouble Rubio criticizes Warren response on same-sex marriage opposition as condescending MORE (R-Fla.) and Ted CruzRafael (Ted) Edward CruzCruz: 'Of course' it's not appropriate to ask China to investigate Bidens Sunday Show Preview: Trump's allies and administration defend decision on Syria O'Rourke raises .5 million in third quarter MORE (R-Texas), who have criticized Obama and backed the embargo. 

All four men are considered likely contenders for the 2016 GOP presidential nomination. 

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"In the end, I think opening up Cuba is probably a good idea," Paul told Tom Roten of WVHU radio in West Virginia, The Associated Press reports.

"The 50-year embargo just hasn't worked," Paul said. "If the goal is regime change, it sure doesn't seem to be working, and probably it punishes the people more than the regime because the regime can blame the embargo for hardship."

Paul made the comments to the Huntington, W.Va., station, just over the border from Kentucky, on Thursday morning, after declining to comment on the issue on Wednesday. 

The Kentucky Republican has a history of libertarianism, and his comments are not a surprise. Former Rep. Ron Paul (R-Texas), the senator's father, introduced a bill to lift the embargo.

Still, the remarks are striking, since it is rare for a mainstream Republican contender for the White House to break firmly from support for the Cuban embargo.

Obama's surprise announcement on Wednesday includes moves to open an embassy in Cuba, and ease travel and economic restrictions. Obama said he would work with Congress to consider fully lifting the embargo.