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Sen. Rand PaulRandal (Rand) Howard PaulConservatives left frustrated as Congress passes big spending bills Senate approves 4B spending bill Some employees' personal data revealed in State Department email breach: report MORE (R-Ky.) is breaking with other Republican presidential hopefuls and backing President Obama's decision to launch talks normalizing relations with Cuba.

Paul criticized the trade and travel embargo on Cuba as ineffective, separating himself from former Florida Gov. Jeb Bush and Sens. Marco RubioMarco Antonio RubioNikki Haley: New York Times ‘knew the facts’ about curtains and still released story March For Our Lives founder leaves group, says he regrets trying to 'embarrass' Rubio Rubio unloads on Turkish chef for 'feasting' Venezuela's Maduro: 'I got pissed' MORE (R-Fla.) and Ted CruzRafael (Ted) Edward CruzViral video shows O’Rourke air-drumming to the Who’s ‘Baba O’Riley’ after Cruz debate Five takeaways from Cruz, O'Rourke's fiery first debate NY Times, McCabe give Trump perfect cover to fire Rosenstein, Sessions MORE (R-Texas), who have criticized Obama and backed the embargo. 

All four men are considered likely contenders for the 2016 GOP presidential nomination. 

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"In the end, I think opening up Cuba is probably a good idea," Paul told Tom Roten of WVHU radio in West Virginia, The Associated Press reports.

"The 50-year embargo just hasn't worked," Paul said. "If the goal is regime change, it sure doesn't seem to be working, and probably it punishes the people more than the regime because the regime can blame the embargo for hardship."

Paul made the comments to the Huntington, W.Va., station, just over the border from Kentucky, on Thursday morning, after declining to comment on the issue on Wednesday. 

The Kentucky Republican has a history of libertarianism, and his comments are not a surprise. Former Rep. Ron Paul (R-Texas), the senator's father, introduced a bill to lift the embargo.

Still, the remarks are striking, since it is rare for a mainstream Republican contender for the White House to break firmly from support for the Cuban embargo.

Obama's surprise announcement on Wednesday includes moves to open an embassy in Cuba, and ease travel and economic restrictions. Obama said he would work with Congress to consider fully lifting the embargo.