Jeb Bush and Marco RubioMarco Antonio RubioSenators pledge action on Saudi journalist’s disappearance Senators concerned as Trump official disputes UN climate change warning Rubio: Response to death of Saudi journalist 'can't be symbolic' MORE’s long-simmering feud in the GOP presidential race burst into the open on Wednesday night over Rubio’s missed votes in the Senate.

Rubio was challenged by a CNBC debate moderator for missing more votes than any other senator this year and being a "young man in a hurry" in his political career, moving on to a new office before finishing out a full term. The Florida lawmaker responded forcefully with a line that won him wild applause from the crowd.

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“That’s exactly what the Republican establishment says too,” Rubio said. “'Why don’t you wait in line?' Wait for what? This country is running out of time, we can’t afford to have another eight years like the last four. ... The time to act is now. The time to turn the page is now.”

But before the moderators could move on, Bush interjected, pointing out that as a fellow Florida resident, Rubio represents him in the Senate.

“I’m a constituent of the senator and I helped him and expected he would show up to work,” the former governor said. “But Marco, when you signed up for this, this was a six-year term. I mean, literally the Senate, what is it a French work week where you have three days to show up? You can campaign, or just resign and let someone else take the job.

"There are a lot of people in Florida living paycheck to paycheck looking for a senator that will fight for them each and every day.”

Rubio responded: "The only reason [Bush is launching this attack] is because we're running for the same position and someone has convinced you that attacking me is going to help you." The crowd cheered.

Rubio had a ready-made comeback, firing back at Bush by saying that he never criticized Arizona Sen. John McCainJohn Sidney McCainMurkowski not worried about a Palin challenge Kavanaugh fight a GOP wake up call, but more is needed MSNBC's Nicolle Wallace: I told Jeb Bush 'he should have punched' Trump 'in the face' MORE in his 2008 run for the White House for missing votes.

“I don’t remember you ever complaining about his voting record, the only reason you’re doing it is because we’re running for the same position and you’re convinced that attacking me is going to help you,” the senator said.

Late Tuesday, Rubio’s hometown paper the Sun Sentinel released a blistering editorial imploring he resign.
 
“Your job is to represent Floridians in the Senate,” the paper wrote. “Either do your job, Sen. Rubio, or resign it.”
 
At the debate, Rubio blasted the paper, which endorsed his Senate candidacy in 2010, pointing out that the editors did not similarly call out then-Sens. Barack ObamaBarack Hussein ObamaDonald Trump Jr. emerges as GOP fundraising force Trump shows peace through strength works after Obama Wake up, Kanye West MORE and John KerryJohn Forbes KerryKerry decries ‘broken’ Washington Christine Blasey Ford has a credibility problem Mellman: Why Kavanaugh should withdraw MORE for missing votes while they ran for office.
 
“It’s evidence of the bias that exists in the American media today,” Rubio said.