Sen. Lindsey GrahamLindsey Olin GrahamGraham emerges as go-to ally for Biden's judicial picks This Thanksgiving, skip the political food fights and talk UFOs instead Biden move to tap oil reserves draws GOP pushback MORE (R-S.C.) says the Republican Party may be forced to support presidential hopeful Ted CruzRafael (Ted) Edward CruzCongress averts shutdown after vaccine mandate fight On The Money — Congress races to keep the lights on House sets up Senate shutdown showdown MORE in order to stop front-runner Donald TrumpDonald TrumpBaldwin calls Trump criticism following 'Rust' shooting 'surreal' Haley hits the stump in South Carolina Mary Trump files to dismiss Trump's lawsuit over NYT tax story MORE.

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"You know Ted Cruz is not my favorite, by any means,” Graham, who dropped his own bid for the White House in December, said in an interview with CBS. “But we may be in a position where we have to rally around Ted Cruz as the only way to stop Donald Trump, and I'm not so sure that would work.”

His comments came with Super Tuesday results indicating Trump would win as many as eight states. They also came a week after Graham joked, “If you killed Ted Cruz on the floor of the Senate, and the trial was in the Senate, nobody could convict you.”

Graham has been a tough critic of both Trump or Cruz. He once said that choosing between the two would be "like being shot or poisoned. I think you get the same result, whether it's quick or it takes a long time."

The South Carolina senator also said on Tuesday that Trump's rhetoric on immigration would guarantee Hillary ClintonHillary Diane Rodham ClintonRepublican Ohio Senate candidate slams JD Vance over previous Trump comments Budowsky: Why GOP donors flock to Manchin and Sinema Countering the ongoing Republican delusion MORE, the Democratic front-runner, would win the general election.

"I think we're about ready to lose to the most dishonest politician in America, Hillary Clinton, and how could you do that? Nominate somebody who's crazy. And I think dishonest beats crazy, that's our problem," Graham said.

"And Donald Trump I think is crazy — the things he says."

Graham said nominating Trump would be a major setback to GOP efforts to attract more Hispanic voters.

"You'll never convince me that Donald Trump is the answer to the problem we have with Hispanics. It will tear the party apart, it will divide conservatism, and we're gonna lose to Hillary Clinton and have the third term of Barack ObamaBarack Hussein ObamaPolitics must accept the reality of multiracial America and disavow racial backlash To empower parents, reinvent schools Senate race in Ohio poses crucial test for Democrats MORE," he said.

Updated at 11:24 p.m.