Sen. Lindsey GrahamLindsey Olin GrahamTensions swirl around Iran as administration to brief Congress Press: Justin Amash breaks ranks with party Overnight Defense: Iran tensions swirl as officials prepare to brief Congress | Trump threatens war would be 'end of Iran' | Graham tells Trump to 'stand firm' | Budget talks begin MORE (R-S.C.) says the Republican Party may be forced to support presidential hopeful Ted CruzRafael (Ted) Edward CruzCruz slams Jim Carrey's 'vicious, angry' painting of Alabama governor after abortion ban Eye-popping number of Dems: I can beat Trump 'SleepyCreepy Joe' and 'Crazy Bernie': Trump seeks to define 2020 Dems with insults MORE in order to stop front-runner Donald TrumpDonald John TrumpThe Hill's Morning Report - White House, Congress: Urgency of now around budget GOP presses Trump to make a deal on spending Democrats wary of handing Trump a win on infrastructure MORE.

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"You know Ted Cruz is not my favorite, by any means,” Graham, who dropped his own bid for the White House in December, said in an interview with CBS. “But we may be in a position where we have to rally around Ted Cruz as the only way to stop Donald Trump, and I'm not so sure that would work.”

His comments came with Super Tuesday results indicating Trump would win as many as eight states. They also came a week after Graham joked, “If you killed Ted Cruz on the floor of the Senate, and the trial was in the Senate, nobody could convict you.”

Graham has been a tough critic of both Trump or Cruz. He once said that choosing between the two would be "like being shot or poisoned. I think you get the same result, whether it's quick or it takes a long time."

The South Carolina senator also said on Tuesday that Trump's rhetoric on immigration would guarantee Hillary ClintonHillary Diane Rodham ClintonThe Memo: Trump faces steep climb to reelection What the Mueller report tells us about Putin, Russia and Trump's election Steve Bullock puts Citizens United decision at center of presidential push MORE, the Democratic front-runner, would win the general election.

"I think we're about ready to lose to the most dishonest politician in America, Hillary Clinton, and how could you do that? Nominate somebody who's crazy. And I think dishonest beats crazy, that's our problem," Graham said.

"And Donald Trump I think is crazy — the things he says."

Graham said nominating Trump would be a major setback to GOP efforts to attract more Hispanic voters.

"You'll never convince me that Donald Trump is the answer to the problem we have with Hispanics. It will tear the party apart, it will divide conservatism, and we're gonna lose to Hillary Clinton and have the third term of Barack ObamaBarack Hussein ObamaFeehery: A whole new season of 'Game of Thrones' Mercury rollback is a direct threat to our children's health Lightfoot takes office as Chicago's first black woman mayor MORE," he said.

Updated at 11:24 p.m.