The Club for Growth’s political apparatus will air more than $500,000 in television ads undercutting three centrist Republicans, including Rep. Fred Upton (R-Mich.), one of the most powerful committee chairmen in the House.

Two wings of the fiscally conservative group, Club for Growth PAC and Club for Growth Action, will also target Rep. Tim Murphy (R-Pa.) and Texas Lt. Gov. David Dewhurst, who is running for retiring Sen. Kay Bailey Hutchison’s (R-Texas) seat.

The ads will start Tuesday and air on cable television for two weeks.

In Michigan, the group calls Upton a “liberal congressman” and blasts him for voting to bail out Wall Street banks, approve earmarks and raise the debt ceiling. While not officially endorsing him, Club for Growth has made no secret of its fondness for Jack Hoogendyk, who is considering making a second go at unseating Upton.

The ads reveal that Upton remains open to attacks from the right despite a tenure atop the House Energy and Commerce Committee that has pleased conservatives, who have hailed the passage of bills to block EPA climate regulations and other rules that industry groups oppose.

“Fred Upton’s been wasting our tax dollars in Washington for 25 years,” the narrator says in the ad. “That’s enough.”

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Club for Growth, which has targeted elected and unelected Republicans it deems too centrist, has endorsed Texas Solicitor General Ted CruzRafael (Ted) Edward CruzGrassley agrees to second Kavanaugh hearing after GOP members revolt FEC: Cruz campaign didn't violate rules with fundraising letter labeled ‘summons’ Cruz criticizes O'Rourke on Dallas shooting: Wish he wasn't 'so quick to always blame the police officer' MORE in the Senate race, so the attack on his opponent is not unexpected.

“This is only the beginning of our efforts in Texas,” said Club for Growth spokesman Barney Keller.

But the early spending against two sitting House Republicans signaled that Upton and Murphy will be top targets for the group’s efforts in 2012 to send fiscally conservative reinforcements to the House.

Two 15-second ads in Pennsylvania target Murphy for supporting union legislation and for approving earmark spending. Club for Growth has not endorsed in the race, but Murphy is fending off a primary challenge from Evan Feinberg, a favorite of the Tea Party movement.

- Ben Geman contributed. This post was updated at 11:47 a.m and 12:40 p.m.

Watch the ad in Texas:

Watch one of the Pennsylvania ads: