Republican Senate candidates hold some sizable cash-on-hand advantages over their Democratic opponents in several key open-seat Senate contests ahead of November. 

Republicans out-raised their Democratic rivals and are sitting on more cash-on-hand in two of the tightest open-seat contests this fall: the race for President Obama's former Senate seat in Illinois and the race to fill the seat of retiring Sen. Jim Bunning (R) in Kentucky.

In Illinois, Rep. Mark KirkMark Steven KirkOn the Trail: Senate GOP hopefuls tie themselves to Trump Biden campaign releases video to explain 'what really happened in Ukraine' Why Republicans are afraid to call a key witness in the impeachment inquiry MORE (R) posted another strong fundraising quarter, raising $3.1 million and reporting $4.4 million cash-on-had. His Democratic opponent, Alexi Giannoulias, raised $2.3 million and reported just over $1.1 million on hand. 

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In Kentucky, Republican Rand PaulRandal (Rand) Howard PaulSenate braces for fight over impeachment whistleblower testimony Pelosi names first-ever House whistleblower ombudsman director The Hill's Morning Report — AG Barr, GOP senators try to rein Trump in MORE out-raised Democrat Jack Conway by $1 million. Paul raised some $2.7 million from July through September to Conway's $1.7 million. The Republican reported $1.4 million cash on hand to just about $1 million for Conway.   

Similarly, in Missouri, New Hampshire, Ohio and Indiana, Republican candidates hold big-cash on-hand leads. 

Rep. Roy BluntRoy Dean BluntSenate braces for fight over impeachment whistleblower testimony Booker, Merkley propose federal facial recognition moratorium GOP senators defend Sondland, Vindman ousters: They weren't 'loyal' MORE (R-Mo.) topped Democrat Robin Carnahan's cash-on-hand number by more than $1.5 million in the Show-Me State. 

In New Hampshire, Republican Kelly AyotteKelly Ann AyotteOn the Trail: Senate GOP hopefuls tie themselves to Trump GOP fears Trump backlash in suburbs Trump makes rare trip to Clinton state, hoping to win back New Hampshire MORE has close to half a million more in the bank than Rep. Paul Hodes (D-N.H.). 

And in Ohio, former Rep. Rob PortmanRobert (Rob) Jones PortmanGOP senators offering bill to cement business provision in Trump tax law Mnuchin defends Treasury regulations on GOP tax law Bipartisan lawmakers introduce bill to combat cyberattacks on state and local governments MORE (R) is absolutely trouncing Democrat Lee Fisher. Portman reported more than $6 million on hand at the end of the third quarter while Fisher has less than $400,000 in the bank.  

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Former Sen. Dan CoatsDaniel (Dan) Ray CoatsThe Hill's Morning Report - Democrats duke it out during Nevada debate Top Democrat on Senate Intel panel pans Trump's DNI pick Trump expected to tap Ambassador to Germany Richard Grenell as acting intel chief MORE (R-Ind.) also has the money edge in Indiana's Senate race, which hasn't appeared competitive for a while. Not only does Coats enjoy a double-digit poll lead, but he's sitting on some $1.3 million, while Rep. Brad Ellsworth (R-Ind.) has less than $900,000 in the bank. 

Another large differential came in a race that has shown no real sign of tightening in recent weeks. In Delaware, Tea Party favorite Christine O'Donnell raised an impressive $3.8 million in the quarter and holds a big cash edge on Democrat Chris CoonsChristopher (Chris) Andrew CoonsDemocratic senators ask DOJ watchdog to expand Giuliani probe Graham warned Pentagon chief about consequences of Africa policy: report Democrats fear rule of law crumbling under Trump MORE

Coons raised just $1.5 million and reported $1.3 million cash-on-hand. O'Donnell is sitting on $2.6 million and continuing to raise sizable amounts of cash online, according to her campaign. 

Still, Coons has led O'Donnell by double digits in every poll of the race for the past month. 

One Democrat who didn't fall victim to the open-seat pattern was Rep. Joe Sestak (D-Pa.), who actually reported slightly more cash-on-hand than former Rep. Pat Toomey (R) despite not raising as much as his Republican rival during the third quarter.

Even as Republicans have a cash advantage in most open-seat races, the financial outlook is brighter for some vulnerable Democratic incumbents. In both Wisconsin and California, Democrats outperformed their Republican challengers. 

Sen. Russ Feingold (D-Wis.) raised $4.2 million and has $3.5 million on hand. That easily tops Republican Ron JohnsonRonald (Ron) Harold JohnsonWhistleblower retaliation: Stop confusing unlawful attacks with politics Congress looks to strengthen hand in State Department following impeachment Senate braces for fight over impeachment whistleblower testimony MORE's $3.3 million haul for the third quarter. Johnson reported just $2 million in the bank.

And in California, Sen. Barbara BoxerBarbara Levy BoxerFormer Democratic Sen. Barbara Boxer joins DC lobbying firm Hillicon Valley: Ocasio-Cortez clashes with former Dem senator over gig worker bill | Software engineer indicted over Capital One breach | Lawmakers push Amazon to remove unsafe products Ocasio-Cortez blasts former Dem senator for helping Lyft fight gig worker bill MORE (D) hauled in some $6.2 million, which edged Republican Carly Fiorina's $5.8 million. The incumbent also has an enormous cash-on-hand advantage in that race, sitting on $6.5 million to Fiornia's $1.8 million.   

Even though the party has lots of ground to defend, another good sign for Democrats are the numbers from the Democratic Senatorial Campaign Committee, which out-performed its Republican counterpart in September. 

The DSCC raised $15.5 million in September for its largest monthly total ever. The National Republican Senatorial Committee hauled in $8.3 million. 

Democrats also lead when it comes to cash on hand — the DSCC reported $25.6 million to the NRSC's $19.2 million.