"After tonight, this has become a three-person race, and we will win the nomination," Rubio told a cheering, screaming crowd.
Rubio also gave his best wishes to his former mentor in Florida politics, Jeb Bush, who quit the GOP race after finishing in single digits in South Carolina.
"I pray for [Bush] and his family tonight as they move forward in other endeavors in their life,” he said.
"Jeb Bush has many things to be proud of," Rubio added. "He is an extraordinary husband, he is an extraordinary father, he was the greatest governor in the history of Florida."
Rubio, who is now well-positioned to capture many of Bush's supporters and major donors, congratulated his former rival for running a campaign based on ideas. 
This was a far cry from complaints that have long emanated from the Rubio camp about the Bush team — and especially his super-PAC Right to Rise — spending millions in a failed attempt to nuke Rubio out of the race.
Rubio said the four of them represented the new generation of conservatism.
"Now the children of the Reagan revolution are ready to assume the mantle of leadership," Rubio said.