Republican presidential candidate Ted CruzRafael (Ted) Edward CruzOvernight Health Care — Presented by Carequest — Colin Powell's death highlights risks for immunocompromised The Senate confirmation process is broken — Senate Democrats can fix it Australian politician on Cruz, vaccines: 'We don't need your lectures, thanks mate' MORE on Thursday angrily slammed rival Donald TrumpDonald TrumpGrant Woods, longtime friend of McCain and former Arizona AG, dies at 67 Super PACs release ad campaign hitting Vance over past comments on Trump Glasgow summit raises stakes for Biden deal MORE for dragging Cruz's wife into the campaign with a series of attacks.

"It's not easy to tick me off. I don't get angry often. But you mess with my wife, you mess with my kids, that'll do it every time," Cruz said in Wisconsin.

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"Donald, you're a sniveling coward. Leave Heidi the hell alone."

Trump first attacked Heidi Cruz on Tuesday night with a tweet threatening to "spill the beans" about her. Trump was responding to an ad from an anti-Trump super-PAC that featured Trump's wife posing nude.

Trump intensified the attacks by sharing a tweet late Wednesday night with an image comparing his wife, Melania, a former model, to Cruz's wife and stating, "A picture is worth a thousand words."

Asked whether he would support Trump if he gets the nomination, Cruz avoided the question.

"I'm going to beat him for the nomination," he said. 

"Donald Trump will not be the nominee," he continued to repeat when pressed.