Kentucky primary voters appear to be spurning the establishment.

Anti-establishment candidates Rand Paul and Daniel Mongiardo have opened up wide leads in their respective Senate primaries, according to a new SurveyUSA poll.

The survey shows Paul, an eye surgeon and son of Rep. Ron Paul (R-Texas), leading Kentucky Secretary of State Trey Grayson 42-27 on the GOP side and Mongiardo, the state's lieutenant governor, leading Kentucky Attorney General Jack Conway 45-27 among Democrats.

The poll also reinforced the toss-up nature of the general election, with Republicans holding a statistically insignificant 43-42 lead on the generic ballot.

Results of head-to-head general election matchups were not provided in the poll, which surveyed more than 1,000 likely primary voters overall and was conducted for local media outlets.

All four candidates recently went up with their first TV ads. The primary is set for May 18.