Sen. Marco RubioMarco RubioWill Republicans stand up to the NRA's insurrection rhetoric? The Hill's Whip List: Senate ObamaCare repeal bill Ivanka Trump turns to House GOP on paid family leave MORE (R-Fla.) believes he can beat Hillary ClintonHillary Rodham ClintonTrump questions special counsel Mueller's objectivity Trump: 'Bothersome' how close Mueller is to Comey House intel panel will interview John Podesta next week: report MORE in the race for the 2016 presidency.

"Multiple people can beat her. Hillary Clinton is not unbeatable," the GOP presidential hopeful told radio host Hugh Hewitt in an interview Friday.

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When asked whether he's concerned about Clinton's extensive foreign policy background if he or another Republican candidate ran against her, Rubio quickly slammed the potential Democratic frontrunner.

"I'd ask her: You were the secretary of State during the first four years of the Obama administration, name one significant foreign policy achievement, now or after you left?", he said.

"The reset with Russia has been a disaster, the Middle East is more unstable today than it's been in I don't know when, our relationships with Latin America and democracy have deteriorated…our partners around the world view us as less reliable."

The Florida lawmaker also weighed in on Lebron James' surprise move back to the Cleveland Cavaliers after four seasons with the Miami Heat.

"I read the article he wrote in Sports Illustrated and it's actually very compelling. And I have a lot of respect," he said.

"The way I view it, he gave us four extraordinary years in Miami, a very special experience and on a personal note he allowed me, along with his teammates, to share with my sons memories they'll treasure for the rest of their lives."