Trump tried to invoke Rubio's disastrous debate performance earlier this month, when Chris Christie, who has since dropped out of the race, bashed the Florida senator for repeating his talking points.
Rubio side-stepped Trump's tactic, instead calling out the businessman for reiterating sound bites instead of providing more details on his healthcare plan.
"Now he's repeating himself," Rubio said as the crowd erupted with cheers. Trump shook his finger for several seconds as the crowd continued to applaud a beaming Rubio.
Cruz and Rubio are battling Trump heading into Super Tuesday next week, where a dozen states hold elections in the GOP race.